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- W2409491250 abstract "Various cellulose and dextran anion exchangers bind bile salts in vitro under conditions of pH and ionic strength resembling those in the lumen of the small intestine. Of these substances, diethylaminoethyl (DEAE) cellulose, guanidoethyl cellulose, and DEAE Sephadex reduced hyper- cholesterolemia when added to the diet of cholesterol-fed cockerels. In addition, DEAE Sephadex reduced serum sterols in normocholesterolemic cockerels and dogs, lowered serum phospholipids and triglycerides in cholesterol-fed hypercholesterolemic cockerels and in normocholesterolemic dogs, and increased fecal excretion of bile acids in hyper- cholesterolemic cockerels. The data indicate that these insoluble cationic polymers exert their hypocholesterolemic effects by interrupting the enterohepatic circulation of bile acids." @default.
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- W2409491250 date "1967-01-01" @default.
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- W2409491250 title "Hypolipidemic effects of orally administered dextran and cellulose anion exchangers in cockerels and dogs" @default.
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- W2409491250 doi "https://doi.org/10.1016/s0022-2275(20)38938-0" @default.
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