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- W2409535544 abstract "N-type Ca2+ channel alpha1B-deficient mice have increased activity (ambulation, repetitive behavior, and rearing combined), suggesting contribution by the N-type Ca2+ channel, localized in the plasma membrane and essential for neurotransmitter release, on motor activity. We evaluated the effect of a 6-wk postweaning period of either individual or group housing on the activity displayed in a novel environment with or without previous habituation. Without habituation, male homozygous alpha1B-deficient mice showed significantly higher activity than wild-type controls, with no influence of the housing condition. When habituated, hyperactivity was seen in individually housed but not group-housed homozygous alpha1B-deficient mice. The results indicate that controlling for housing condition can be important when phenotypically analyzing mutant mice." @default.
- W2409535544 created "2016-06-24" @default.
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- W2409535544 date "2006-09-01" @default.
- W2409535544 modified "2023-09-24" @default.
- W2409535544 title "Individual and group housing in N-type Ca2+ channel alpha1B subunit-deficient mice differently affect motor activity." @default.
- W2409535544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16995646" @default.
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