Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409575794> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2409575794 endingPage "E404" @default.
- W2409575794 startingPage "E397" @default.
- W2409575794 abstract "This study examined the influence of acute exercise on the ability of insulin-like growth factor I (IGF-I) to stimulate protein synthesis in an isolated in vitro soleus muscle preparation in female C57Bl/6 mice aged 5, 12, and 24 mo. Gastrocnemius muscles were analyzed for IGF-I receptor mRNA levels, IGF-I receptor number, and IGF-I receptor binding capacities and affinity constants. IGF-I (20 nM) was unable to stimulate rates of protein synthesis in the 12- and 24-mo-old control animals. These animals demonstrated declines in IGF-I receptor protein. After acute exercise, IGF-I receptor mRNA was elevated, IGF-I receptor protein levels were unaffected, and rates of protein synthesis were stimulated by IGF-I in the 12- and 24-mo-old animals. Acute exercise significantly increased IGF-I receptor binding capacity and affinity constants in the 24- but not the 12-mo-old animals. We conclude that acute exercise can restore the action of IGF-I in aged muscle, potentially by increasing the IGF-I receptor binding capacity and affinity or as a result of factors downstream of the IGF-I receptor." @default.
- W2409575794 created "2016-06-24" @default.
- W2409575794 creator A5010704818 @default.
- W2409575794 creator A5022528845 @default.
- W2409575794 creator A5024312016 @default.
- W2409575794 creator A5046031030 @default.
- W2409575794 date "1997-03-01" @default.
- W2409575794 modified "2023-10-14" @default.
- W2409575794 title "Acute exercise attenuates age-associated resistance to insulin-like growth factor I" @default.
- W2409575794 cites W1507116771 @default.
- W2409575794 cites W1577717356 @default.
- W2409575794 cites W1972512989 @default.
- W2409575794 cites W1983649348 @default.
- W2409575794 cites W1983904045 @default.
- W2409575794 cites W1986659280 @default.
- W2409575794 cites W2005385842 @default.
- W2409575794 cites W2022700305 @default.
- W2409575794 cites W2025771789 @default.
- W2409575794 cites W2029729823 @default.
- W2409575794 cites W2043813981 @default.
- W2409575794 cites W2102123572 @default.
- W2409575794 cites W2110855530 @default.
- W2409575794 cites W2134812217 @default.
- W2409575794 cites W2332493691 @default.
- W2409575794 cites W4241709163 @default.
- W2409575794 cites W4377298280 @default.
- W2409575794 doi "https://doi.org/10.1152/ajpendo.1997.272.3.e397" @default.
- W2409575794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9124545" @default.
- W2409575794 hasPublicationYear "1997" @default.
- W2409575794 type Work @default.
- W2409575794 sameAs 2409575794 @default.
- W2409575794 citedByCount "24" @default.
- W2409575794 countsByYear W24095757942012 @default.
- W2409575794 countsByYear W24095757942013 @default.
- W2409575794 countsByYear W24095757942014 @default.
- W2409575794 countsByYear W24095757942015 @default.
- W2409575794 countsByYear W24095757942017 @default.
- W2409575794 countsByYear W24095757942019 @default.
- W2409575794 countsByYear W24095757942021 @default.
- W2409575794 crossrefType "journal-article" @default.
- W2409575794 hasAuthorship W2409575794A5010704818 @default.
- W2409575794 hasAuthorship W2409575794A5022528845 @default.
- W2409575794 hasAuthorship W2409575794A5024312016 @default.
- W2409575794 hasAuthorship W2409575794A5046031030 @default.
- W2409575794 hasConcept C112446052 @default.
- W2409575794 hasConcept C126322002 @default.
- W2409575794 hasConcept C134018914 @default.
- W2409575794 hasConcept C144174609 @default.
- W2409575794 hasConcept C170493617 @default.
- W2409575794 hasConcept C185592680 @default.
- W2409575794 hasConcept C2775960820 @default.
- W2409575794 hasConcept C2777391703 @default.
- W2409575794 hasConcept C2779306644 @default.
- W2409575794 hasConcept C2780689927 @default.
- W2409575794 hasConcept C71924100 @default.
- W2409575794 hasConcept C86803240 @default.
- W2409575794 hasConceptScore W2409575794C112446052 @default.
- W2409575794 hasConceptScore W2409575794C126322002 @default.
- W2409575794 hasConceptScore W2409575794C134018914 @default.
- W2409575794 hasConceptScore W2409575794C144174609 @default.
- W2409575794 hasConceptScore W2409575794C170493617 @default.
- W2409575794 hasConceptScore W2409575794C185592680 @default.
- W2409575794 hasConceptScore W2409575794C2775960820 @default.
- W2409575794 hasConceptScore W2409575794C2777391703 @default.
- W2409575794 hasConceptScore W2409575794C2779306644 @default.
- W2409575794 hasConceptScore W2409575794C2780689927 @default.
- W2409575794 hasConceptScore W2409575794C71924100 @default.
- W2409575794 hasConceptScore W2409575794C86803240 @default.
- W2409575794 hasIssue "3" @default.
- W2409575794 hasLocation W24095757941 @default.
- W2409575794 hasLocation W24095757942 @default.
- W2409575794 hasOpenAccess W2409575794 @default.
- W2409575794 hasPrimaryLocation W24095757941 @default.
- W2409575794 hasRelatedWork W138803513 @default.
- W2409575794 hasRelatedWork W1524756587 @default.
- W2409575794 hasRelatedWork W1986132654 @default.
- W2409575794 hasRelatedWork W2010140898 @default.
- W2409575794 hasRelatedWork W2082140668 @default.
- W2409575794 hasRelatedWork W2103096725 @default.
- W2409575794 hasRelatedWork W2135403984 @default.
- W2409575794 hasRelatedWork W4234612679 @default.
- W2409575794 hasRelatedWork W4377298280 @default.
- W2409575794 hasRelatedWork W2063271975 @default.
- W2409575794 hasVolume "272" @default.
- W2409575794 isParatext "false" @default.
- W2409575794 isRetracted "false" @default.
- W2409575794 magId "2409575794" @default.
- W2409575794 workType "article" @default.