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- W2409599319 abstract "目的 观察苯诱发再障模型及氨磷汀干预的病理改变.方法156只雄性CD1小鼠,随机分为6组,1个对照组,1个干预组,4个实验组(B1、B2、B3、B4).实验组所给苯剂量分别为0.5、1.0、1.5和2.0 ml/kg;对照组单纯注射玉米油;干预组每次给苯半小时前,腹腔注射氨磷汀200 mg/kg.各组均每周3次注射,以玉米油补足4 ml/kg.各实验组分别于给苯前及给苯10、15、20、25次2 d后,称重动物,观察小鼠一般情况并检测血象,尸检后取一根股骨、肝和脾,称重并进行组织病理学观察以及增殖细胞核抗原(PCNA)、末端脱氧核甘酸转移酶介导的dUTP缺口末端标记(TUNEL)检测.结果(1)与对照组比较,各实验组小鼠均有部分指标改变,但仅有B4组在给苯25次后全部指标与对照组比较,差异有统计学意义(P＜0.05),B4组体重和脾体比值分别比对照组下降18.51%、63.86%,差异有统计学意义(P＜0.01);血细胞数目减少,部分骨髓涂片出现油滴,骨髓细胞形态学和组织病理学观察均显示造血细胞减少,非造血细胞增加,肝、脾出现再障的病理改变.(2)干预组与B4(再障)组比较,小鼠一般情况、肝脾和骨髓的病理变化等各项指标均有明显改善,PCNA、TUNEL检测在对照组、B4组和干预组之间差异有统计学意义(P＜0.05).结论(1)建立苯诱发小鼠再生障碍性贫血模型,可以通过CD1小鼠每周3次皮下注射2 ml/kg苯(共25次)获得.(2)氨磷汀对苯致再障具有一定的保护作用。" @default.
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- W2409599319 date "2006-07-01" @default.
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- W2409599319 title "Model of benzene induced aplastic anemia in mice and pathological changes of intervention of Amifostine" @default.
- W2409599319 doi "https://doi.org/10.3760/cma.j.issn.1001-9391.2006.07.015" @default.
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