FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409681897> ?p ?o ?g. }

• W2409681897 endingPage "87" @default.
• W2409681897 startingPage "76" @default.
• W2409681897 abstract "Phosphorylation is a reversible post-translational modification of proteins that controls a plethora of cellular processes and triggers specific physiological responses, for which there is a need to develop tools to characterize phosphorylated targets efficiently. Here, a combinatorial library of triazine-based synthetic ligands comprising 64 small molecules has been rationally designed, synthesized and screened for the enrichment of phosphorylated peptides. The lead candidate (coined A8A3), composed of histidine and phenylalanine mimetic components, showed high binding capacity and selectivity for binding mono- and multi-phosphorylated peptides at pH 3. Ligand A8A3 was coupled onto both cross-linked agarose and magnetic nanoparticles, presenting higher binding capacities (100-fold higher) when immobilized on the magnetic support. The magnetic adsorbent was further screened against a tryptic digest of two phosphorylated proteins (α- and β-caseins) and one non-phosphorylated protein (bovine serum albumin, BSA). The MALDI-TOF mass spectra of the eluted peptides allowed the identification of nine phosphopeptides, comprising both mono- and multi-phosphorylated peptides." @default.
• W2409681897 created "2016-06-24" @default.
• W2409681897 creator A5007256008 @default.
• W2409681897 creator A5010689272 @default.
• W2409681897 creator A5018392457 @default.
• W2409681897 creator A5066241536 @default.
• W2409681897 creator A5071806024 @default.
• W2409681897 date "2016-07-01" @default.
• W2409681897 modified "2023-09-26" @default.
• W2409681897 title "Mimicking nature: Phosphopeptide enrichment using combinatorial libraries of affinity ligands" @default.
• W2409681897 cites W1595837951 @default.
• W2409681897 cites W1643771641 @default.
• W2409681897 cites W1973383826 @default.
• W2409681897 cites W1980122435 @default.
• W2409681897 cites W1982005616 @default.
• W2409681897 cites W1982673963 @default.
• W2409681897 cites W1983836332 @default.
• W2409681897 cites W1986977491 @default.
• W2409681897 cites W1995660345 @default.
• W2409681897 cites W1996444571 @default.
• W2409681897 cites W1997269703 @default.
• W2409681897 cites W1997370760 @default.
• W2409681897 cites W1998123477 @default.
• W2409681897 cites W2003856466 @default.
• W2409681897 cites W2006415570 @default.
• W2409681897 cites W2006957104 @default.
• W2409681897 cites W2014872858 @default.
• W2409681897 cites W2018853005 @default.
• W2409681897 cites W2021343906 @default.
• W2409681897 cites W2028387937 @default.
• W2409681897 cites W2030402654 @default.
• W2409681897 cites W2035076912 @default.
• W2409681897 cites W2037470357 @default.
• W2409681897 cites W2041337564 @default.
• W2409681897 cites W2048472959 @default.
• W2409681897 cites W2050206405 @default.
• W2409681897 cites W2053481244 @default.
• W2409681897 cites W2055556379 @default.
• W2409681897 cites W2068439250 @default.
• W2409681897 cites W2078004298 @default.
• W2409681897 cites W2078591297 @default.
• W2409681897 cites W2085703761 @default.
• W2409681897 cites W2088433073 @default.
• W2409681897 cites W2092654973 @default.
• W2409681897 cites W2092895104 @default.
• W2409681897 cites W2103730178 @default.
• W2409681897 cites W2105686031 @default.
• W2409681897 cites W2125574061 @default.
• W2409681897 cites W2126346850 @default.
• W2409681897 cites W2131036059 @default.
• W2409681897 cites W2132005699 @default.
• W2409681897 cites W2140969503 @default.
• W2409681897 cites W2144437180 @default.
• W2409681897 cites W2170736411 @default.
• W2409681897 cites W2422737200 @default.
• W2409681897 cites W81452715 @default.
• W2409681897 doi "https://doi.org/10.1016/j.chroma.2016.06.032" @default.
• W2409681897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27345211" @default.
• W2409681897 hasPublicationYear "2016" @default.
• W2409681897 type Work @default.
• W2409681897 sameAs 2409681897 @default.
• W2409681897 citedByCount "10" @default.
• W2409681897 countsByYear W24096818972016 @default.
• W2409681897 countsByYear W24096818972019 @default.
• W2409681897 countsByYear W24096818972020 @default.
• W2409681897 countsByYear W24096818972021 @default.
• W2409681897 crossrefType "journal-article" @default.
• W2409681897 hasAuthorship W2409681897A5007256008 @default.
• W2409681897 hasAuthorship W2409681897A5010689272 @default.
• W2409681897 hasAuthorship W2409681897A5018392457 @default.
• W2409681897 hasAuthorship W2409681897A5066241536 @default.
• W2409681897 hasAuthorship W2409681897A5071806024 @default.
• W2409681897 hasConcept C104317684 @default.
• W2409681897 hasConcept C11960822 @default.
• W2409681897 hasConcept C167625842 @default.
• W2409681897 hasConcept C178790620 @default.
• W2409681897 hasConcept C185592680 @default.
• W2409681897 hasConcept C21951064 @default.
• W2409681897 hasConcept C2776303721 @default.
• W2409681897 hasConcept C2776471321 @default.
• W2409681897 hasConcept C2778476535 @default.
• W2409681897 hasConcept C2779281246 @default.
• W2409681897 hasConcept C2779933727 @default.
• W2409681897 hasConcept C43617362 @default.
• W2409681897 hasConcept C55493867 @default.
• W2409681897 hasConcept C73826308 @default.
• W2409681897 hasConcept C86807702 @default.
• W2409681897 hasConceptScore W2409681897C104317684 @default.
• W2409681897 hasConceptScore W2409681897C11960822 @default.
• W2409681897 hasConceptScore W2409681897C167625842 @default.
• W2409681897 hasConceptScore W2409681897C178790620 @default.
• W2409681897 hasConceptScore W2409681897C185592680 @default.
• W2409681897 hasConceptScore W2409681897C21951064 @default.
• W2409681897 hasConceptScore W2409681897C2776303721 @default.
• W2409681897 hasConceptScore W2409681897C2776471321 @default.
• W2409681897 hasConceptScore W2409681897C2778476535 @default.
• W2409681897 hasConceptScore W2409681897C2779281246 @default.
• W2409681897 hasConceptScore W2409681897C2779933727 @default.

• next