Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409697773> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2409697773 endingPage "72" @default.
- W2409697773 startingPage "68" @default.
- W2409697773 abstract "INTRODUCTION Cystic fibrosis (CF) patients are at high risk for vitamin K deficiency. Vitamin K supplementation dose has not been clearly defined, and the effects of the supplementation are very ambiguous. Therefore, the aim of the present study was to assess body resources of vitamin K and determine the suitability of the coagulation parameters in the assessment of vitamin K deficiency in patients undergoing supplementation. MATERIALS AND METHODS The study comprised 30 CF patients aged from 1.5 to 32 years. In all patients, the concentration of the undercarboxylated prothrombin (prothrombin induced by vitamin K deficiency--PIVKA-II), as a marker of vitamin K deficiency, was estimated. For comparison of the diagnostic value of existing methods of assessment of vitamin K status, the coagulation parameters were evaluated (prothrombin ratio and INR). RESULTS In spite of applied supplementation vitamin K status was not normal in all CF patients. Increased PIVKA-II concentrations (3.3-97 ng/ml) were found in 8 out of 30 (26.7%) patients, when the cut-off value of 2 ng/ml was used. Abnormal PIVKA-II levels corresponded to pathological values of the coagulation parameters only in one patient. In the remaining 7 CF subjects with increased concentration of the undercarboxylated prothrombin, coagulation parameters were normal. CONCLUSIONS Vitamin K deficiency occurs in CF patients despite applied supplementation. The accurate supplementation dose should be estimated individually and the assessment of its effectiveness requires studies allowing to determine the real body resources of vitamin K. The coagulation parameters are not a good indicator of vitamin K deficiency." @default.
- W2409697773 created "2016-06-24" @default.
- W2409697773 creator A5013184084 @default.
- W2409697773 creator A5016528957 @default.
- W2409697773 creator A5024086017 @default.
- W2409697773 creator A5035237325 @default.
- W2409697773 creator A5038269907 @default.
- W2409697773 creator A5046810443 @default.
- W2409697773 creator A5089028432 @default.
- W2409697773 creator A5090039135 @default.
- W2409697773 date "2010-01-01" @default.
- W2409697773 modified "2023-09-23" @default.
- W2409697773 title "Vitamin K deficiency in patients with CF despite supplementation" @default.
- W2409697773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20608431" @default.
- W2409697773 hasPublicationYear "2010" @default.
- W2409697773 type Work @default.
- W2409697773 sameAs 2409697773 @default.
- W2409697773 citedByCount "2" @default.
- W2409697773 countsByYear W24096977732015 @default.
- W2409697773 countsByYear W24096977732017 @default.
- W2409697773 crossrefType "journal-article" @default.
- W2409697773 hasAuthorship W2409697773A5013184084 @default.
- W2409697773 hasAuthorship W2409697773A5016528957 @default.
- W2409697773 hasAuthorship W2409697773A5024086017 @default.
- W2409697773 hasAuthorship W2409697773A5035237325 @default.
- W2409697773 hasAuthorship W2409697773A5038269907 @default.
- W2409697773 hasAuthorship W2409697773A5046810443 @default.
- W2409697773 hasAuthorship W2409697773A5089028432 @default.
- W2409697773 hasAuthorship W2409697773A5090039135 @default.
- W2409697773 hasConcept C126322002 @default.
- W2409697773 hasConcept C134018914 @default.
- W2409697773 hasConcept C16124881 @default.
- W2409697773 hasConcept C2776938444 @default.
- W2409697773 hasConcept C2776940978 @default.
- W2409697773 hasConcept C2778382381 @default.
- W2409697773 hasConcept C2779520540 @default.
- W2409697773 hasConcept C2780434524 @default.
- W2409697773 hasConcept C2993590494 @default.
- W2409697773 hasConcept C71924100 @default.
- W2409697773 hasConcept C90924648 @default.
- W2409697773 hasConceptScore W2409697773C126322002 @default.
- W2409697773 hasConceptScore W2409697773C134018914 @default.
- W2409697773 hasConceptScore W2409697773C16124881 @default.
- W2409697773 hasConceptScore W2409697773C2776938444 @default.
- W2409697773 hasConceptScore W2409697773C2776940978 @default.
- W2409697773 hasConceptScore W2409697773C2778382381 @default.
- W2409697773 hasConceptScore W2409697773C2779520540 @default.
- W2409697773 hasConceptScore W2409697773C2780434524 @default.
- W2409697773 hasConceptScore W2409697773C2993590494 @default.
- W2409697773 hasConceptScore W2409697773C71924100 @default.
- W2409697773 hasConceptScore W2409697773C90924648 @default.
- W2409697773 hasIssue "1" @default.
- W2409697773 hasLocation W24096977731 @default.
- W2409697773 hasLocation W24096977732 @default.
- W2409697773 hasOpenAccess W2409697773 @default.
- W2409697773 hasPrimaryLocation W24096977731 @default.
- W2409697773 hasRelatedWork W1935841659 @default.
- W2409697773 hasRelatedWork W1939859013 @default.
- W2409697773 hasRelatedWork W1990620169 @default.
- W2409697773 hasRelatedWork W2044502481 @default.
- W2409697773 hasRelatedWork W205891413 @default.
- W2409697773 hasRelatedWork W2069426575 @default.
- W2409697773 hasRelatedWork W2092512421 @default.
- W2409697773 hasRelatedWork W2123358601 @default.
- W2409697773 hasRelatedWork W2153121023 @default.
- W2409697773 hasRelatedWork W2313403587 @default.
- W2409697773 hasRelatedWork W2375389066 @default.
- W2409697773 hasRelatedWork W2744724791 @default.
- W2409697773 hasRelatedWork W2887849896 @default.
- W2409697773 hasRelatedWork W2907225620 @default.
- W2409697773 hasRelatedWork W2923748501 @default.
- W2409697773 hasRelatedWork W2953455558 @default.
- W2409697773 hasRelatedWork W3039402558 @default.
- W2409697773 hasRelatedWork W52933767 @default.
- W2409697773 hasRelatedWork W63741375 @default.
- W2409697773 hasRelatedWork W190482598 @default.
- W2409697773 hasVolume "14" @default.
- W2409697773 isParatext "false" @default.
- W2409697773 isRetracted "false" @default.
- W2409697773 magId "2409697773" @default.
- W2409697773 workType "article" @default.