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• W2409710963 endingPage "868" @default.
• W2409710963 startingPage "868" @default.
• W2409710963 abstract "Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases with an extensive range of substrate specificities. Collectively, these enzymes are able to degrade various components of extracellular matrix (ECM) proteins. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26); and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, and MMP-16). The alterations made to the ECM by MMPs might contribute in skin wrinkling, a characteristic of premature skin aging. In photocarcinogenesis, degradation of ECM is the initial step towards tumor cell invasion, to invade both the basement membrane and the surrounding stroma that mainly comprises fibrillar collagens. Additionally, MMPs are involved in angiogenesis, which promotes cancer cell growth and migration. In this review, we focus on the present knowledge about premature skin aging and skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, with our main focus on members of the MMP family and their functions." @default.
• W2409710963 created "2016-06-24" @default.
• W2409710963 creator A5048378082 @default.
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• W2409710963 creator A5071964293 @default.
• W2409710963 creator A5082143201 @default.
• W2409710963 date "2016-06-02" @default.
• W2409710963 modified "2023-10-18" @default.
• W2409710963 title "Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis" @default.
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