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- W2409748604 abstract "The role of the T lymphocyte in the pathophysiology of rheumatoid arthritis (RA) remains somewhat unclear. On the one hand, T cells are abundantly present in the inflamed synovium, and in some animal models T cells can be identified as the main effector cells of the inflammatory response. Moreover, the demonstration that human leukocyte antigen (HLA)-DR genotypes are associated with the risk for RA points at the T cell, because the function of the class II major histocompatibility complex (MHC) molecule in the immune response is exerted through binding to the T-cell receptor. On the other hand, it was demonstrated that the human rheumatoid synovium does not present abundant evidence for T-cell activation, and cyclosporin-A, the one conventional antirheumatic agent that is believed to work almost exclusively through inhibition of T cells, has only limited efficacy in RA." @default.
- W2409748604 created "2016-06-24" @default.
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- W2409748604 date "2015-12-23" @default.
- W2409748604 modified "2023-09-24" @default.
- W2409748604 title "B-cell Directed Therapy" @default.
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- W2409748604 doi "https://doi.org/10.1007/978-3-319-13108-5_5" @default.
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