FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409773039> ?p ?o ?g. }

• W2409773039 abstract "More than 70 drugs present on the Swiss market can cause drug-induced long QT syndrome (LQTS), which is associated with torsades de pointes (TdP) arrhythmias, potentially leading to sudden cardiac death. Basic and clinical investigations performed during the last decade have helped a better understanding of the mechanisms and risk factors of this serious public health problem. In their vast majority, QT interval prolonging drugs block the human ERG (hERG) channel involved in the repolarisation phase of the cardiac action potential, and thus lengthen the QT interval. Beside the well-known QT interval prolonging action of class IA, IC and III anti-arrhythmic drugs, many antibiotics, neurotropic, antifungal, and antimalarial drugs are also able to cause drug-induced LQTS. Reviewing the literature indicates that the risk of QT interval prolongation and TdP is increased in females, in patients with organic heart diseases and hypokalaemia. Furthermore in a few cases, genetic factors have also been reported. However thus far, no genetic test is available to detect at-risk patients, and in consequence, drug prescribers are still relying only on the clinical history and findings to perform an evaluation of the risk. Treatment of drug-induced LQTS and TdP includes identifying and withdrawing the culprit drug(s), infusing magnesium and, in resistant cases acceleration of the heart rate. In this review article we provide a list of QT interval prolonging drugs adapted to the pharmaceuticals found on the Swiss market that can be used as a check-list for drug prescribers and at-risk patients." @default.
• W2409773039 created "2016-06-24" @default.
• W2409773039 creator A5002278517 @default.
• W2409773039 creator A5003179880 @default.
• W2409773039 creator A5015176657 @default.
• W2409773039 creator A5019469136 @default.
• W2409773039 creator A5042222100 @default.
• W2409773039 creator A5056912526 @default.
• W2409773039 creator A5072851099 @default.
• W2409773039 creator A5091827487 @default.
• W2409773039 date "2004-11-27" @default.
• W2409773039 modified "2023-10-18" @default.
• W2409773039 title "Molecular and clinical determinants of drug-induced long QT syndrome: an iatrogenic channelopathy" @default.
• W2409773039 cites W1586405772 @default.
• W2409773039 cites W1597827786 @default.
• W2409773039 cites W1898032589 @default.
• W2409773039 cites W1905285594 @default.
• W2409773039 cites W1966545771 @default.
• W2409773039 cites W1966907929 @default.
• W2409773039 cites W1967931001 @default.
• W2409773039 cites W1968098810 @default.
• W2409773039 cites W1979035808 @default.
• W2409773039 cites W1982613279 @default.
• W2409773039 cites W1984414919 @default.
• W2409773039 cites W1988210113 @default.
• W2409773039 cites W1991053107 @default.
• W2409773039 cites W2014198017 @default.
• W2409773039 cites W2018706474 @default.
• W2409773039 cites W2024225383 @default.
• W2409773039 cites W2027987251 @default.
• W2409773039 cites W2035197728 @default.
• W2409773039 cites W2046508780 @default.
• W2409773039 cites W2048169841 @default.
• W2409773039 cites W2052976216 @default.
• W2409773039 cites W2054195660 @default.
• W2409773039 cites W2060802584 @default.
• W2409773039 cites W2061578778 @default.
• W2409773039 cites W2066538341 @default.
• W2409773039 cites W2073223574 @default.
• W2409773039 cites W2074705578 @default.
• W2409773039 cites W2084756418 @default.
• W2409773039 cites W2085007473 @default.
• W2409773039 cites W2092661856 @default.
• W2409773039 cites W2093132242 @default.
• W2409773039 cites W2094555615 @default.
• W2409773039 cites W2099664572 @default.
• W2409773039 cites W2106478893 @default.
• W2409773039 cites W2107763854 @default.
• W2409773039 cites W2108590750 @default.
• W2409773039 cites W2108736561 @default.
• W2409773039 cites W2110061674 @default.
• W2409773039 cites W2120642757 @default.
• W2409773039 cites W2121912757 @default.
• W2409773039 cites W2125271591 @default.
• W2409773039 cites W2127815448 @default.
• W2409773039 cites W2129910735 @default.
• W2409773039 cites W2131308754 @default.
• W2409773039 cites W2134192812 @default.
• W2409773039 cites W2143003039 @default.
• W2409773039 cites W2157559661 @default.
• W2409773039 cites W2157788198 @default.
• W2409773039 cites W2158013260 @default.
• W2409773039 cites W2158152684 @default.
• W2409773039 cites W2162233259 @default.
• W2409773039 cites W2163175442 @default.
• W2409773039 cites W2163863644 @default.
• W2409773039 cites W2165907819 @default.
• W2409773039 cites W2170592109 @default.
• W2409773039 cites W2284531888 @default.
• W2409773039 cites W2416776549 @default.
• W2409773039 cites W2417935403 @default.
• W2409773039 cites W2471757827 @default.
• W2409773039 doi "https://doi.org/10.4414/smw.2004.10532" @default.
• W2409773039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15616901" @default.
• W2409773039 hasPublicationYear "2004" @default.
• W2409773039 type Work @default.
• W2409773039 sameAs 2409773039 @default.
• W2409773039 citedByCount "27" @default.
• W2409773039 countsByYear W24097730392012 @default.
• W2409773039 countsByYear W24097730392013 @default.
• W2409773039 countsByYear W24097730392014 @default.
• W2409773039 countsByYear W24097730392016 @default.
• W2409773039 countsByYear W24097730392023 @default.
• W2409773039 crossrefType "journal-article" @default.
• W2409773039 hasAuthorship W2409773039A5002278517 @default.
• W2409773039 hasAuthorship W2409773039A5003179880 @default.
• W2409773039 hasAuthorship W2409773039A5015176657 @default.
• W2409773039 hasAuthorship W2409773039A5019469136 @default.
• W2409773039 hasAuthorship W2409773039A5042222100 @default.
• W2409773039 hasAuthorship W2409773039A5056912526 @default.
• W2409773039 hasAuthorship W2409773039A5072851099 @default.
• W2409773039 hasAuthorship W2409773039A5091827487 @default.
• W2409773039 hasBestOaLocation W24097730391 @default.
• W2409773039 hasConcept C118441451 @default.
• W2409773039 hasConcept C126322002 @default.
• W2409773039 hasConcept C164705383 @default.
• W2409773039 hasConcept C170734499 @default.
• W2409773039 hasConcept C177713679 @default.
• W2409773039 hasConcept C2775935837 @default.
• W2409773039 hasConcept C2778094803 @default.

• next