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- W2409819809 abstract "AbstractOur understanding of the detailed mechanisms of specific promoter/enhancer DNA-binding site recognition by transcriptional regulatory factors is primarily based on three-dimensional structural studies using the methods of X-ray crystallography and NMR. Vast amount of accumulated experimental data have revealed the basic principles of protein–DNA complex formation paving the way for better modeling and prediction of DNA-binding properties of transcription factors. In this review, our intent is to provide a general overview of the three-dimensional structures of DNA-bound transcriptional regulators starting from the basic principles of specific DNA recognition and ending with high-order multiprotein–DNA complexes.Key wordsTranscription factorgene expressioncrystal structureDNA-binding domainDNA-binding motifprotein–DNA interactioncooperative DNA bindingDNA recognitionpromoterenhancer" @default.
- W2409819809 created "2016-06-24" @default.
- W2409819809 creator A5005916247 @default.
- W2409819809 creator A5025774887 @default.
- W2409819809 date "2010-01-01" @default.
- W2409819809 modified "2023-09-27" @default.
- W2409819809 title "Three-Dimensional Structures of DNA-Bound Transcriptional Regulators" @default.
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- W2409819809 doi "https://doi.org/10.1007/978-1-60761-854-6_4" @default.
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