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• W2409835495 abstract "We synthesized (+)-decursin derivatives substituted with cinnamoyl- and phenyl propionyl groups originating from (+)-CGK062 and screened them using a cell-based assay to detect relative luciferase reporter activity. Of this series, compound 8b, in which a 3-acetoxy cinnamoyl group was introduced, most potently inhibited (97.0%) the Wnt/β-catenin pathway. Specifically, compound 8b dose-dependently inhibited Wnt3a-induced expression of the β-catenin response transcription (CRT) and increased β-catenin degradation in HEK293 reporter cells. Furthermore, compound 8b suppressed expression of the downstream β-catenin target genes cyclin D1 and c-myc and suppressed PC3 cell growth in a concentration-dependent manner." @default.
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• W2409835495 date "2016-08-01" @default.
• W2409835495 modified "2023-10-14" @default.
• W2409835495 title "Synthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/β-catenin pathway" @default.
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• W2409835495 doi "https://doi.org/10.1016/j.bmcl.2016.06.029" @default.
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