Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409912912> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2409912912 endingPage "8" @default.
- W2409912912 startingPage "234" @default.
- W2409912912 abstract "The innate immune system is essential for controlling viral infection. Hepatitis C virus (HCV) is a causative agent of hepatocellular carcinoma. HCV evades host innate immune response and maintains persistent infection. RIG-I is a cytoplasmic viral RNA sensor and triggers the innate immune response. The Riplet ubiquitin ligase mediates K63-linked polyubiquitination of RIG-I, which is essential for RIG-I activation. Previous studies have shown that HCV NS3-4A protease cleaves RIG-I adaptor MAVS to escape host antiviral response. However, MAVS cleavage is supposed to be not sufficient for viral chronicity. Recently, we found that NS3-4A cleaves both MAVS and Riplet to attenuate RIG-I activation. These findings indicate that HCV NS3-4A cleaves several proteins to shut off antiviral innate immune response." @default.
- W2409912912 created "2016-06-24" @default.
- W2409912912 creator A5043184323 @default.
- W2409912912 creator A5071402791 @default.
- W2409912912 creator A5089860635 @default.
- W2409912912 date "2015-02-01" @default.
- W2409912912 modified "2023-09-23" @default.
- W2409912912 title "[Chronic hepatitis C virus infection attenuates host antiviral innate immune response]." @default.
- W2409912912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25764676" @default.
- W2409912912 hasPublicationYear "2015" @default.
- W2409912912 type Work @default.
- W2409912912 sameAs 2409912912 @default.
- W2409912912 citedByCount "2" @default.
- W2409912912 countsByYear W24099129122015 @default.
- W2409912912 countsByYear W24099129122016 @default.
- W2409912912 crossrefType "journal-article" @default.
- W2409912912 hasAuthorship W2409912912A5043184323 @default.
- W2409912912 hasAuthorship W2409912912A5071402791 @default.
- W2409912912 hasAuthorship W2409912912A5089860635 @default.
- W2409912912 hasConcept C132379496 @default.
- W2409912912 hasConcept C136449434 @default.
- W2409912912 hasConcept C159047783 @default.
- W2409912912 hasConcept C183786373 @default.
- W2409912912 hasConcept C203014093 @default.
- W2409912912 hasConcept C2522874641 @default.
- W2409912912 hasConcept C2776178377 @default.
- W2409912912 hasConcept C2776408679 @default.
- W2409912912 hasConcept C2776954689 @default.
- W2409912912 hasConcept C62478195 @default.
- W2409912912 hasConcept C86803240 @default.
- W2409912912 hasConcept C8891405 @default.
- W2409912912 hasConcept C95444343 @default.
- W2409912912 hasConceptScore W2409912912C132379496 @default.
- W2409912912 hasConceptScore W2409912912C136449434 @default.
- W2409912912 hasConceptScore W2409912912C159047783 @default.
- W2409912912 hasConceptScore W2409912912C183786373 @default.
- W2409912912 hasConceptScore W2409912912C203014093 @default.
- W2409912912 hasConceptScore W2409912912C2522874641 @default.
- W2409912912 hasConceptScore W2409912912C2776178377 @default.
- W2409912912 hasConceptScore W2409912912C2776408679 @default.
- W2409912912 hasConceptScore W2409912912C2776954689 @default.
- W2409912912 hasConceptScore W2409912912C62478195 @default.
- W2409912912 hasConceptScore W2409912912C86803240 @default.
- W2409912912 hasConceptScore W2409912912C8891405 @default.
- W2409912912 hasConceptScore W2409912912C95444343 @default.
- W2409912912 hasIssue "2" @default.
- W2409912912 hasLocation W24099129121 @default.
- W2409912912 hasOpenAccess W2409912912 @default.
- W2409912912 hasPrimaryLocation W24099129121 @default.
- W2409912912 hasRelatedWork W2014712837 @default.
- W2409912912 hasRelatedWork W2031107017 @default.
- W2409912912 hasRelatedWork W2033567830 @default.
- W2409912912 hasRelatedWork W2098676417 @default.
- W2409912912 hasRelatedWork W2128847991 @default.
- W2409912912 hasRelatedWork W2145107075 @default.
- W2409912912 hasRelatedWork W2154322581 @default.
- W2409912912 hasRelatedWork W2246171720 @default.
- W2409912912 hasRelatedWork W2313366690 @default.
- W2409912912 hasRelatedWork W2757571618 @default.
- W2409912912 hasRelatedWork W2802867560 @default.
- W2409912912 hasRelatedWork W2885498200 @default.
- W2409912912 hasRelatedWork W291106506 @default.
- W2409912912 hasRelatedWork W2942804565 @default.
- W2409912912 hasRelatedWork W2973869873 @default.
- W2409912912 hasRelatedWork W3000561753 @default.
- W2409912912 hasRelatedWork W3029878722 @default.
- W2409912912 hasRelatedWork W3035042392 @default.
- W2409912912 hasRelatedWork W3043844061 @default.
- W2409912912 hasRelatedWork W3175609408 @default.
- W2409912912 hasVolume "73" @default.
- W2409912912 isParatext "false" @default.
- W2409912912 isRetracted "false" @default.
- W2409912912 magId "2409912912" @default.
- W2409912912 workType "article" @default.