Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409925166> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2409925166 endingPage "152" @default.
- W2409925166 startingPage "149" @default.
- W2409925166 abstract "Objective To analyze the expression level and clinical significance of the preferentially expressed antigen of melanoma (PRAME) transcripts in patients with acute myeloid leukemia (AML).Methods Real-time quantitative polymerase chain reaction with EvaGreen dye was established to detect the expression level of PRAME transcripts in the bone marrow mononuclear cells of 56 AML cases and 20 controls. The clinical association of PRAME transcripts was analyzed. Results The PRAME transcripts were 0-1. 46% (median 0. 18%) and 0-21 618. 09% (median 9. 79%) in controls and AML cases,respectively (P＜0.01). Among the FAB subtypes, those with M1, M2, M3 and M4 had significantly higher level of PRAME transcripts than controls. However, those with M5 had similar level of PRAME transcripts as controls. There was a significantly negative correlation between the PRAME transcripts and cytogenetic risk groups (r= -0. 438, P= 0. 001). Cases in low risk had significantly higher level of PRAME transcripts than those in intermediate and high risk. Among cases with AML-M2, those with t(8;21) had significantly higher level of PRAME transcripts (135.06%-21 618.09%, median 2201.88%) than those without t(8;21) (0. 14%-1696.30%, median 17. 97%)(P=0. 002). In a patient with sequential samples, PRAME transcripts significantly decreased after induction therapy and significantly increased after relapse. Conclusion The PRAME transcript was highly expressed in AML patients and was a favorable marker of prognosis. Quantification of PRAME transcript can be used in monitoring disease status of AML.Key words: real-time quantitative PCR; EvaGreen dye; PRAME gene; acute myeloid leukemia" @default.
- W2409925166 created "2016-06-24" @default.
- W2409925166 creator A5001583563 @default.
- W2409925166 creator A5012152127 @default.
- W2409925166 creator A5014048532 @default.
- W2409925166 creator A5020923032 @default.
- W2409925166 creator A5026015949 @default.
- W2409925166 creator A5042103774 @default.
- W2409925166 creator A5045245977 @default.
- W2409925166 creator A5071863676 @default.
- W2409925166 creator A5087745821 @default.
- W2409925166 date "2010-04-01" @default.
- W2409925166 modified "2023-09-23" @default.
- W2409925166 title "Quantification of the PRAME transcripts in patients with acute myeloid leukemia" @default.
- W2409925166 doi "https://doi.org/10.3760/cma.j.issn.1003-9406.2010.02.007" @default.
- W2409925166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20376794" @default.
- W2409925166 hasPublicationYear "2010" @default.
- W2409925166 type Work @default.
- W2409925166 sameAs 2409925166 @default.
- W2409925166 citedByCount "1" @default.
- W2409925166 countsByYear W24099251662016 @default.
- W2409925166 crossrefType "journal-article" @default.
- W2409925166 hasAuthorship W2409925166A5001583563 @default.
- W2409925166 hasAuthorship W2409925166A5012152127 @default.
- W2409925166 hasAuthorship W2409925166A5014048532 @default.
- W2409925166 hasAuthorship W2409925166A5020923032 @default.
- W2409925166 hasAuthorship W2409925166A5026015949 @default.
- W2409925166 hasAuthorship W2409925166A5042103774 @default.
- W2409925166 hasAuthorship W2409925166A5045245977 @default.
- W2409925166 hasAuthorship W2409925166A5071863676 @default.
- W2409925166 hasAuthorship W2409925166A5087745821 @default.
- W2409925166 hasConcept C104317684 @default.
- W2409925166 hasConcept C126322002 @default.
- W2409925166 hasConcept C137061746 @default.
- W2409925166 hasConcept C143998085 @default.
- W2409925166 hasConcept C202751555 @default.
- W2409925166 hasConcept C2778729363 @default.
- W2409925166 hasConcept C2780007613 @default.
- W2409925166 hasConcept C48023723 @default.
- W2409925166 hasConcept C55493867 @default.
- W2409925166 hasConcept C71924100 @default.
- W2409925166 hasConcept C86803240 @default.
- W2409925166 hasConcept C90924648 @default.
- W2409925166 hasConceptScore W2409925166C104317684 @default.
- W2409925166 hasConceptScore W2409925166C126322002 @default.
- W2409925166 hasConceptScore W2409925166C137061746 @default.
- W2409925166 hasConceptScore W2409925166C143998085 @default.
- W2409925166 hasConceptScore W2409925166C202751555 @default.
- W2409925166 hasConceptScore W2409925166C2778729363 @default.
- W2409925166 hasConceptScore W2409925166C2780007613 @default.
- W2409925166 hasConceptScore W2409925166C48023723 @default.
- W2409925166 hasConceptScore W2409925166C55493867 @default.
- W2409925166 hasConceptScore W2409925166C71924100 @default.
- W2409925166 hasConceptScore W2409925166C86803240 @default.
- W2409925166 hasConceptScore W2409925166C90924648 @default.
- W2409925166 hasIssue "2" @default.
- W2409925166 hasLocation W24099251661 @default.
- W2409925166 hasLocation W24099251662 @default.
- W2409925166 hasOpenAccess W2409925166 @default.
- W2409925166 hasPrimaryLocation W24099251661 @default.
- W2409925166 hasRelatedWork W2032409940 @default.
- W2409925166 hasRelatedWork W2077167899 @default.
- W2409925166 hasRelatedWork W2080185239 @default.
- W2409925166 hasRelatedWork W2091537353 @default.
- W2409925166 hasRelatedWork W2286502341 @default.
- W2409925166 hasRelatedWork W2337448843 @default.
- W2409925166 hasRelatedWork W2351548211 @default.
- W2409925166 hasRelatedWork W2369338388 @default.
- W2409925166 hasRelatedWork W2378465753 @default.
- W2409925166 hasRelatedWork W2379576022 @default.
- W2409925166 hasRelatedWork W2387238559 @default.
- W2409925166 hasRelatedWork W2392570562 @default.
- W2409925166 hasRelatedWork W2409777304 @default.
- W2409925166 hasRelatedWork W2418465661 @default.
- W2409925166 hasRelatedWork W2524649484 @default.
- W2409925166 hasRelatedWork W2564488576 @default.
- W2409925166 hasRelatedWork W3030492528 @default.
- W2409925166 hasRelatedWork W3030755940 @default.
- W2409925166 hasRelatedWork W3033429820 @default.
- W2409925166 hasRelatedWork W3139674091 @default.
- W2409925166 hasVolume "27" @default.
- W2409925166 isParatext "false" @default.
- W2409925166 isRetracted "false" @default.
- W2409925166 magId "2409925166" @default.
- W2409925166 workType "article" @default.