Matches in SemOpenAlex for { <https://semopenalex.org/work/W2409941608> ?p ?o ?g. }
- W2409941608 endingPage "975" @default.
- W2409941608 startingPage "970" @default.
- W2409941608 abstract "To present a case with 17,20-desmolase activity deficiency in which in vitro fertilization (IVF) served not only as a therapeutic approach but also as a diagnostic tool for the specificity of the enzymatic deficiency. IVF in the patient under study compared with a control group. All women treated with pure follicle-stimulating hormone (FSH). IVF program at the Instituto Valenciano de Infertilidad. A patient with primary amenorrhea, who was the subject under study, and seven normally cycling control patients undergoing IVF in the same series. IVF, steroidogenesis in vitro of granulosa-luteal cell obtained at ovum pick-up. Oocyte fertilization and embryo cleavage. Serum and follicular fluid (FF) levels of estradiol (E2), progesterone (P), testosterone (T), androstendione (A), 17α-hydroxyprogesterone (17-OHP). In vitro accumulation of E2 and P. Ovulation induction with FSH was successful in achieving follicular development despite low circulating E2. Fertilization and cleavage rates were similar to the control subjects. The patient developed ovarian hyperstimulation. The lack of 17,20-desmolase activity was detected by normal P levels in serum and FF, high 17-OHP, and low T, A, and E2 levels in serum and FF. Granulosaluteal cell cultures in the presence of T restored normal E2 and P production in response to gonadotropins. In patients with 17,20-desmolase deficiency, follicular development, oocyte maturation, and fertilization can take place in a low estrogenic environment." @default.
- W2409941608 created "2016-06-24" @default.
- W2409941608 creator A5011458075 @default.
- W2409941608 creator A5015002150 @default.
- W2409941608 creator A5050701007 @default.
- W2409941608 creator A5057850877 @default.
- W2409941608 creator A5078349873 @default.
- W2409941608 date "1991-05-01" @default.
- W2409941608 modified "2023-09-27" @default.
- W2409941608 title "In vitro fertilization as a diagnostic and therapeutic tool in a patient with partial 17,20-desmolase deficiency" @default.
- W2409941608 cites W1556798853 @default.
- W2409941608 cites W1764010703 @default.
- W2409941608 cites W1979358923 @default.
- W2409941608 cites W1979520020 @default.
- W2409941608 cites W1989597923 @default.
- W2409941608 cites W1999503791 @default.
- W2409941608 cites W2009677864 @default.
- W2409941608 cites W2012856899 @default.
- W2409941608 cites W2015216655 @default.
- W2409941608 cites W2018326902 @default.
- W2409941608 cites W2020925984 @default.
- W2409941608 cites W2030108667 @default.
- W2409941608 cites W2044042112 @default.
- W2409941608 cites W2065880784 @default.
- W2409941608 cites W2069976990 @default.
- W2409941608 cites W2081842823 @default.
- W2409941608 cites W2092918346 @default.
- W2409941608 cites W2131391777 @default.
- W2409941608 cites W2168319499 @default.
- W2409941608 cites W2266940243 @default.
- W2409941608 cites W2267601507 @default.
- W2409941608 cites W2281290623 @default.
- W2409941608 cites W2415788331 @default.
- W2409941608 cites W2570390508 @default.
- W2409941608 doi "https://doi.org/10.1016/s0015-0282(16)54308-8" @default.
- W2409941608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1902422" @default.
- W2409941608 hasPublicationYear "1991" @default.
- W2409941608 type Work @default.
- W2409941608 sameAs 2409941608 @default.
- W2409941608 citedByCount "75" @default.
- W2409941608 countsByYear W24099416082012 @default.
- W2409941608 countsByYear W24099416082013 @default.
- W2409941608 countsByYear W24099416082014 @default.
- W2409941608 countsByYear W24099416082015 @default.
- W2409941608 countsByYear W24099416082017 @default.
- W2409941608 countsByYear W24099416082018 @default.
- W2409941608 countsByYear W24099416082019 @default.
- W2409941608 countsByYear W24099416082020 @default.
- W2409941608 countsByYear W24099416082021 @default.
- W2409941608 countsByYear W24099416082022 @default.
- W2409941608 countsByYear W24099416082023 @default.
- W2409941608 crossrefType "journal-article" @default.
- W2409941608 hasAuthorship W2409941608A5011458075 @default.
- W2409941608 hasAuthorship W2409941608A5015002150 @default.
- W2409941608 hasAuthorship W2409941608A5050701007 @default.
- W2409941608 hasAuthorship W2409941608A5057850877 @default.
- W2409941608 hasAuthorship W2409941608A5078349873 @default.
- W2409941608 hasConcept C126322002 @default.
- W2409941608 hasConcept C134018914 @default.
- W2409941608 hasConcept C16685009 @default.
- W2409941608 hasConcept C187785154 @default.
- W2409941608 hasConcept C196843134 @default.
- W2409941608 hasConcept C2776188440 @default.
- W2409941608 hasConcept C2776690073 @default.
- W2409941608 hasConcept C2777702977 @default.
- W2409941608 hasConcept C2778478619 @default.
- W2409941608 hasConcept C2781230225 @default.
- W2409941608 hasConcept C512716672 @default.
- W2409941608 hasConcept C526171541 @default.
- W2409941608 hasConcept C62231903 @default.
- W2409941608 hasConcept C6557445 @default.
- W2409941608 hasConcept C71315377 @default.
- W2409941608 hasConcept C71924100 @default.
- W2409941608 hasConcept C80446465 @default.
- W2409941608 hasConcept C86803240 @default.
- W2409941608 hasConcept C88972607 @default.
- W2409941608 hasConcept C95444343 @default.
- W2409941608 hasConceptScore W2409941608C126322002 @default.
- W2409941608 hasConceptScore W2409941608C134018914 @default.
- W2409941608 hasConceptScore W2409941608C16685009 @default.
- W2409941608 hasConceptScore W2409941608C187785154 @default.
- W2409941608 hasConceptScore W2409941608C196843134 @default.
- W2409941608 hasConceptScore W2409941608C2776188440 @default.
- W2409941608 hasConceptScore W2409941608C2776690073 @default.
- W2409941608 hasConceptScore W2409941608C2777702977 @default.
- W2409941608 hasConceptScore W2409941608C2778478619 @default.
- W2409941608 hasConceptScore W2409941608C2781230225 @default.
- W2409941608 hasConceptScore W2409941608C512716672 @default.
- W2409941608 hasConceptScore W2409941608C526171541 @default.
- W2409941608 hasConceptScore W2409941608C62231903 @default.
- W2409941608 hasConceptScore W2409941608C6557445 @default.
- W2409941608 hasConceptScore W2409941608C71315377 @default.
- W2409941608 hasConceptScore W2409941608C71924100 @default.
- W2409941608 hasConceptScore W2409941608C80446465 @default.
- W2409941608 hasConceptScore W2409941608C86803240 @default.
- W2409941608 hasConceptScore W2409941608C88972607 @default.
- W2409941608 hasConceptScore W2409941608C95444343 @default.
- W2409941608 hasIssue "5" @default.