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- W2409978125 abstract "Lumpy skin disease (LSD) is a poxvirus infection of cattle in which cuta neous nodules and lymphadenitis develop. The disease occurs sporadically in cattle in African countries. Generally the prevalence is low but serious epidemics may develop at intervals. Much of the epidemiological information suggests that transmission is indirect and that insects playa part in the spread of LSD. The main clinical signs are those of fever, the development of multiple, painful skin nodules and lymphadenitis. As lesions progress the center of the cutaneous lesions becomes hard, necrotic and difficult to remove (so-called sitfasts ). On pathological examination lesions may be present in internal organs. Histology of the lesions shows the presence of intracytoplasmic inclusion bodies in epithelial and mononuclear cells. A clinically similar disease caused by bovid herpesvirus 2 (BHV2) is known as pseudo-lumpy skin disease (pseudo LSD). Bovid herpesvirus 2 is also associated with another clinical syndrome, that of mammillitis. Pseudo-LSD disease has been reported mainly from Africa and mammillitis from more temperate regions. In both syndromes skin nodules develop. Those on the teat break down readily into ulcers. On the hairy skin, nodules of the superficial layers become necrotic and, with the exudate, form a dry scab which eventually separates, leaving a hairless pigmented area. Histopathology of early lesions shows syncytial formation and eosinophilic intranu clear inclusion bodies. Confirmation of LSD and pseudo-LSD is most accurately obtained by virus isola tion. In 1929 a disease called pseudo-urticaria was recognized for the first time in Northern Rhodesia (now Zambia). In the following decade the same dis ease was reported in other areas of Zambia and in the 1940s it was described in South Africa where it became known as Ngamiland cattle disease. Since then this disease, now called lympy skin disease (LSD), has been recognized in East Africa in 1957 and subsequently in more northern countries of Africa. Confusion existed between true LSD and a somewhat milder disease with similar characteristics now known as pseudo-lumpy skin disease (pseudo-" @default.
- W2409978125 created "2016-06-24" @default.
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- W2409978125 date "1981-01-01" @default.
- W2409978125 modified "2023-09-27" @default.
- W2409978125 title "13. LUMPY SKIN DISEASE AND PSElJDO-LUMPY SKIN DISEASE" @default.
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