FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410006827> ?p ?o ?g. }

• W2410006827 endingPage "3570" @default.
• W2410006827 startingPage "3565" @default.
• W2410006827 abstract "The thioredoxin (Trx)-thioredoxin reductase (TrxR) system plays a key role in maintaining the cellular redox balance with Trx being over-expressed in a number of cancers. Inhibition of TrxR is an important strategy for anti-cancer drug discovery. The natural product pleurotin is a well-known irreversible inhibitor of TrxR. The cytotoxicity data for benzo[1,2,4]triazin-7-ones showed very strong correlation (Pearson correlation coefficients ∼0.8) to pleurotin using National Cancer Institute COMPARE analysis. A new 3-CF3 substituted benzo[1,2,4]triazin-7-one gave submicromolar inhibition of TrxR, although the parent compound 1,3-diphenylbenzo[1,2,4]triazin-7-one was more cytotoxic against cancer cell lines. Benzo[1,2,4]triazin-7-ones exhibited different types of reversible inhibition of TrxR, and cyclic voltammetry showed characteristic quasi-reversible redox processes. Cell viability studies indicated strong dependence of cytotoxicity on substitution at the 6-position of the 1,3-diphenylbenzo[1,2,4]triazin-7-one ring." @default.
• W2410006827 created "2016-06-24" @default.
• W2410006827 creator A5006710672 @default.
• W2410006827 creator A5017422174 @default.
• W2410006827 creator A5017465733 @default.
• W2410006827 creator A5019315489 @default.
• W2410006827 creator A5040966447 @default.
• W2410006827 creator A5043375520 @default.
• W2410006827 creator A5054965386 @default.
• W2410006827 creator A5071332464 @default.
• W2410006827 creator A5085675603 @default.
• W2410006827 date "2016-08-01" @default.
• W2410006827 modified "2023-10-14" @default.
• W2410006827 title "Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition" @default.
• W2410006827 cites W1964517366 @default.
• W2410006827 cites W1966708809 @default.
• W2410006827 cites W1968130089 @default.
• W2410006827 cites W1969026076 @default.
• W2410006827 cites W1990702839 @default.
• W2410006827 cites W1996894145 @default.
• W2410006827 cites W1998508069 @default.
• W2410006827 cites W2008820074 @default.
• W2410006827 cites W2020170893 @default.
• W2410006827 cites W2021536101 @default.
• W2410006827 cites W2032295024 @default.
• W2410006827 cites W2034028960 @default.
• W2410006827 cites W2059112580 @default.
• W2410006827 cites W2083298717 @default.
• W2410006827 cites W2087312216 @default.
• W2410006827 cites W2103650142 @default.
• W2410006827 cites W2113860045 @default.
• W2410006827 cites W2114918609 @default.
• W2410006827 cites W2120509326 @default.
• W2410006827 cites W2313670566 @default.
• W2410006827 cites W2951947361 @default.
• W2410006827 cites W4251161705 @default.
• W2410006827 doi "https://doi.org/10.1016/j.bmc.2016.05.066" @default.
• W2410006827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27290691" @default.
• W2410006827 hasPublicationYear "2016" @default.
• W2410006827 type Work @default.
• W2410006827 sameAs 2410006827 @default.
• W2410006827 citedByCount "20" @default.
• W2410006827 countsByYear W24100068272017 @default.
• W2410006827 countsByYear W24100068272018 @default.
• W2410006827 countsByYear W24100068272019 @default.
• W2410006827 countsByYear W24100068272020 @default.
• W2410006827 countsByYear W24100068272021 @default.
• W2410006827 countsByYear W24100068272022 @default.
• W2410006827 countsByYear W24100068272023 @default.
• W2410006827 crossrefType "journal-article" @default.
• W2410006827 hasAuthorship W2410006827A5006710672 @default.
• W2410006827 hasAuthorship W2410006827A5017422174 @default.
• W2410006827 hasAuthorship W2410006827A5017465733 @default.
• W2410006827 hasAuthorship W2410006827A5019315489 @default.
• W2410006827 hasAuthorship W2410006827A5040966447 @default.
• W2410006827 hasAuthorship W2410006827A5043375520 @default.
• W2410006827 hasAuthorship W2410006827A5054965386 @default.
• W2410006827 hasAuthorship W2410006827A5071332464 @default.
• W2410006827 hasAuthorship W2410006827A5085675603 @default.
• W2410006827 hasBestOaLocation W24100068272 @default.
• W2410006827 hasConcept C109316439 @default.
• W2410006827 hasConcept C121608353 @default.
• W2410006827 hasConcept C134651460 @default.
• W2410006827 hasConcept C181199279 @default.
• W2410006827 hasConcept C185592680 @default.
• W2410006827 hasConcept C202751555 @default.
• W2410006827 hasConcept C2777737464 @default.
• W2410006827 hasConcept C3623737 @default.
• W2410006827 hasConcept C54355233 @default.
• W2410006827 hasConcept C55493867 @default.
• W2410006827 hasConcept C71240020 @default.
• W2410006827 hasConcept C86803240 @default.
• W2410006827 hasConcept C96232424 @default.
• W2410006827 hasConceptScore W2410006827C109316439 @default.
• W2410006827 hasConceptScore W2410006827C121608353 @default.
• W2410006827 hasConceptScore W2410006827C134651460 @default.
• W2410006827 hasConceptScore W2410006827C181199279 @default.
• W2410006827 hasConceptScore W2410006827C185592680 @default.
• W2410006827 hasConceptScore W2410006827C202751555 @default.
• W2410006827 hasConceptScore W2410006827C2777737464 @default.
• W2410006827 hasConceptScore W2410006827C3623737 @default.
• W2410006827 hasConceptScore W2410006827C54355233 @default.
• W2410006827 hasConceptScore W2410006827C55493867 @default.
• W2410006827 hasConceptScore W2410006827C71240020 @default.
• W2410006827 hasConceptScore W2410006827C86803240 @default.
• W2410006827 hasConceptScore W2410006827C96232424 @default.
• W2410006827 hasFunder F4320313981 @default.
• W2410006827 hasFunder F4320321002 @default.
• W2410006827 hasIssue "16" @default.
• W2410006827 hasLocation W24100068271 @default.
• W2410006827 hasLocation W24100068272 @default.
• W2410006827 hasLocation W24100068273 @default.
• W2410006827 hasLocation W24100068274 @default.
• W2410006827 hasLocation W24100068275 @default.
• W2410006827 hasOpenAccess W2410006827 @default.
• W2410006827 hasPrimaryLocation W24100068271 @default.
• W2410006827 hasRelatedWork W1591929009 @default.
• W2410006827 hasRelatedWork W1668614192 @default.

• next