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- W2410009326 abstract "Although type 2 diabetes is often characterized by normal or high mineral density (BMD), diabetes is associated with increased risk of fracture. This paradoxical phenomenon in type 2 diabetes may be explained by poorer bone quality by detrimental collagen cross-links in bone. Recently, we showed that the alteration of enzymatic and nonenzymatic crosslinking in could be important for explaining the variation of fracture susceptibility in diabetes (Osteoporos Int, 2006. Epub ahead of print). In this review, we describe that low turnover bone, hyperglycemia, mildly hyperhomocysteinemia, and vitamin B(6) insufficiency are crucial determinants of detrimental crosslinking of collagen in diabetes." @default.
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- W2410009326 date "2006-08-01" @default.
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- W2410009326 title "[Poor bone quality in diabetes: detrimental collagen cross-link pattern reduces bone strength without change in bone mineral density]." @default.
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