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• W2410009618 abstract "Abstract Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. Hallmarks of autoimmune disease pathogenesis are abnormal CD4+ and CD8+ T cell activation. We investigated the TSCM subset in 55, 34, 43, and 5 patients with acquired aplastic anemia (AA), autoimmune uveitis, systemic lupus erythematosus, and sickle cell disease, respectively, as well as in 41 age-matched healthy controls. CD8+ TSCM frequency was significantly increased in AA compared with healthy controls. An increased CD8+ TSCM frequency at diagnosis was associated with responsiveness to immunosuppressive therapy, and an elevated CD8+ TSCM population after immunosuppressive therapy correlated with treatment failure or relapse in AA patients. IFN-γ and IL-2 production was significantly increased in various CD8+ and CD4+ T cell subsets in AA patients, including CD8+ and CD4+ TSCMs. CD8+ TSCM frequency was also increased in patients with autoimmune uveitis or sickle cell disease. A positive correlation between CD4+ and CD8+ TSCM frequencies was found in AA, autoimmune uveitis, and systemic lupus erythematosus. Evaluation of PD-1, CD160, and CD244 expression revealed that TSCMs were less exhausted compared with other types of memory T cells. Our results suggest that the CD8+ TSCM subset is a novel biomarker and a potential therapeutic target for AA." @default.
• W2410009618 created "2016-06-24" @default.
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• W2410009618 date "2016-02-15" @default.
• W2410009618 modified "2023-10-12" @default.
• W2410009618 title "Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8⁺Memory Stem Cells in Acquired Aplastic Anemia" @default.
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• W2410009618 doi "https://doi.org/10.4049/jimmunol.1501739" @default.
• W2410009618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4744506" @default.
• W2410009618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26764034" @default.
• W2410009618 hasPublicationYear "2016" @default.
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