FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410009664> ?p ?o ?g. }

• W2410009664 endingPage "88" @default.
• W2410009664 startingPage "1279" @default.
• W2410009664 abstract "Dengue is a viral disease of expanding global incidence without cures. Here we present a drug repositioning system (DenguePredict) leveraging upon a unique drug treatment database and vast amounts of disease- and drug-related data. We first constructed a large-scale genetic disease network with enriched dengue genetics data curated from biomedical literature. We applied a network-based ranking algorithm to find dengue-related diseases from the disease network. We then developed a novel algorithm to prioritize FDA-approved drugs from dengue-related diseases to treat dengue. When tested in a de-novo validation setting, DenguePredict found the only two drugs tested in clinical trials for treating dengue and ranked them highly: chloroquine ranked at top 0.96% and ivermectin at top 22.75%. We showed that drugs targeting immune systems and arachidonic acid metabolism-related apoptotic pathways might represent innovative drugs to treat dengue. In summary, DenguePredict, by combining comprehensive disease- and drug-related data and novel algorithms, may greatly facilitate drug discovery for dengue." @default.
• W2410009664 created "2016-06-24" @default.
• W2410009664 creator A5030457222 @default.
• W2410009664 creator A5050134236 @default.
• W2410009664 date "2015-01-01" @default.
• W2410009664 modified "2023-09-27" @default.
• W2410009664 title "DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue." @default.
• W2410009664 cites W1517711897 @default.
• W2410009664 cites W1925517254 @default.
• W2410009664 cites W1978224608 @default.
• W2410009664 cites W1986392977 @default.
• W2410009664 cites W1989590412 @default.
• W2410009664 cites W1994658365 @default.
• W2410009664 cites W1995332691 @default.
• W2410009664 cites W2001636656 @default.
• W2410009664 cites W2005132321 @default.
• W2410009664 cites W2005286637 @default.
• W2410009664 cites W2007438750 @default.
• W2410009664 cites W2007816528 @default.
• W2410009664 cites W2010457001 @default.
• W2410009664 cites W2019707847 @default.
• W2410009664 cites W2023660652 @default.
• W2410009664 cites W2030531674 @default.
• W2410009664 cites W2030704316 @default.
• W2410009664 cites W2062584010 @default.
• W2410009664 cites W2062941476 @default.
• W2410009664 cites W2067756806 @default.
• W2410009664 cites W2070789802 @default.
• W2410009664 cites W2078705463 @default.
• W2410009664 cites W2078720156 @default.
• W2410009664 cites W2095377201 @default.
• W2410009664 cites W2103518727 @default.
• W2410009664 cites W2105924489 @default.
• W2410009664 cites W2109252922 @default.
• W2410009664 cites W2113072832 @default.
• W2410009664 cites W2113535256 @default.
• W2410009664 cites W2116868464 @default.
• W2410009664 cites W2117092707 @default.
• W2410009664 cites W2119412782 @default.
• W2410009664 cites W2119939554 @default.
• W2410009664 cites W2121604817 @default.
• W2410009664 cites W2127864764 @default.
• W2410009664 cites W2128054164 @default.
• W2410009664 cites W2129442719 @default.
• W2410009664 cites W2130771676 @default.
• W2410009664 cites W2137052779 @default.
• W2410009664 cites W2137546662 @default.
• W2410009664 cites W2137632714 @default.
• W2410009664 cites W2138512826 @default.
• W2410009664 cites W2147541161 @default.
• W2410009664 cites W2149023901 @default.
• W2410009664 cites W2154896031 @default.
• W2410009664 cites W2159583324 @default.
• W2410009664 cites W2165276227 @default.
• W2410009664 cites W2188188738 @default.
• W2410009664 cites W2763995789 @default.
• W2410009664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4765554" @default.
• W2410009664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26958268" @default.
• W2410009664 hasPublicationYear "2015" @default.
• W2410009664 type Work @default.
• W2410009664 sameAs 2410009664 @default.
• W2410009664 citedByCount "5" @default.
• W2410009664 countsByYear W24100096642014 @default.
• W2410009664 countsByYear W24100096642016 @default.
• W2410009664 countsByYear W24100096642017 @default.
• W2410009664 countsByYear W24100096642021 @default.
• W2410009664 crossrefType "journal-article" @default.
• W2410009664 hasAuthorship W2410009664A5030457222 @default.
• W2410009664 hasAuthorship W2410009664A5050134236 @default.
• W2410009664 hasConcept C103637391 @default.
• W2410009664 hasConcept C126322002 @default.
• W2410009664 hasConcept C159047783 @default.
• W2410009664 hasConcept C2777474118 @default.
• W2410009664 hasConcept C2779134260 @default.
• W2410009664 hasConcept C2780035454 @default.
• W2410009664 hasConcept C533803919 @default.
• W2410009664 hasConcept C535046627 @default.
• W2410009664 hasConcept C60644358 @default.
• W2410009664 hasConcept C70721500 @default.
• W2410009664 hasConcept C71924100 @default.
• W2410009664 hasConcept C74187038 @default.
• W2410009664 hasConcept C86803240 @default.
• W2410009664 hasConcept C98274493 @default.
• W2410009664 hasConceptScore W2410009664C103637391 @default.
• W2410009664 hasConceptScore W2410009664C126322002 @default.
• W2410009664 hasConceptScore W2410009664C159047783 @default.
• W2410009664 hasConceptScore W2410009664C2777474118 @default.
• W2410009664 hasConceptScore W2410009664C2779134260 @default.
• W2410009664 hasConceptScore W2410009664C2780035454 @default.
• W2410009664 hasConceptScore W2410009664C533803919 @default.
• W2410009664 hasConceptScore W2410009664C535046627 @default.
• W2410009664 hasConceptScore W2410009664C60644358 @default.
• W2410009664 hasConceptScore W2410009664C70721500 @default.
• W2410009664 hasConceptScore W2410009664C71924100 @default.
• W2410009664 hasConceptScore W2410009664C74187038 @default.
• W2410009664 hasConceptScore W2410009664C86803240 @default.
• W2410009664 hasConceptScore W2410009664C98274493 @default.
• W2410009664 hasLocation W24100096641 @default.

• next