FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410046771> ?p ?o ?g. }

• W2410046771 endingPage "11819" @default.
• W2410046771 startingPage "11812" @default.
• W2410046771 abstract "Nanopore-based sensors have been studied extensively as potential tools for DNA sequencing, characterization of epigenetic modifications such as 5-methylcytosine, and detection of microRNA biomarkers. In the studies described here, the α-hemolysin protein nanopore embedded in a lipid bilayer was used for the detection and characterization of interstrand cross-links in duplex DNA. Interstrand cross-links are important lesions in medicinal chemistry and toxicology because they prevent the strand separation that is required for read-out of genetic information from DNA in cells. In addition, interstrand cross-links are used for the stabilization of duplex DNA in structural biology and materials science. Cross-linked DNA fragments produced unmistakable current signatures in the nanopore experiment. Some cross-linked substrates gave irreversible current blocks of >10 min, while others produced long current blocks (10-100 s) before the double-stranded DNA cross-link translocated through the α-hemolysin channel in a voltage-driven manner. The duration of the current block for the different cross-linked substrates examined here may be dictated by the stability of the duplex region left in the vestibule of the nanopore following partial unzipping of the cross-linked DNA. Construction of calibration curves measuring the frequency of cross-link blocking events (1/τon) as a function of cross-link concentration enabled quantitative determination of the amounts of cross-linked DNA present in samples. The unique current signatures generated by cross-linked DNA in the α-HL nanopore may enable the detection and characterization of DNA cross-links that are important in toxicology, medicine, and materials science." @default.
• W2410046771 created "2016-06-24" @default.
• W2410046771 creator A5013602438 @default.
• W2410046771 creator A5021414632 @default.
• W2410046771 creator A5039374362 @default.
• W2410046771 creator A5042859426 @default.
• W2410046771 creator A5079033224 @default.
• W2410046771 creator A5080903560 @default.
• W2410046771 date "2015-11-18" @default.
• W2410046771 modified "2023-10-17" @default.
• W2410046771 title "Characterization of Interstrand DNA–DNA Cross-Links Using the α-Hemolysin Protein Nanopore" @default.
• W2410046771 cites W1496246291 @default.
• W2410046771 cites W1964142943 @default.
• W2410046771 cites W1966834115 @default.
• W2410046771 cites W1971777367 @default.
• W2410046771 cites W1976343889 @default.
• W2410046771 cites W1983338915 @default.
• W2410046771 cites W1984812591 @default.
• W2410046771 cites W1993527536 @default.
• W2410046771 cites W1994677283 @default.
• W2410046771 cites W1999393795 @default.
• W2410046771 cites W1999723219 @default.
• W2410046771 cites W2006070503 @default.
• W2410046771 cites W2007928020 @default.
• W2410046771 cites W2008638513 @default.
• W2410046771 cites W2017004978 @default.
• W2410046771 cites W2025583382 @default.
• W2410046771 cites W2027505528 @default.
• W2410046771 cites W2028553114 @default.
• W2410046771 cites W2030683115 @default.
• W2410046771 cites W2034325392 @default.
• W2410046771 cites W2034541418 @default.
• W2410046771 cites W2034875560 @default.
• W2410046771 cites W2046341407 @default.
• W2410046771 cites W2058659693 @default.
• W2410046771 cites W2059755977 @default.
• W2410046771 cites W2060374698 @default.
• W2410046771 cites W2061568414 @default.
• W2410046771 cites W2070557115 @default.
• W2410046771 cites W2073105380 @default.
• W2410046771 cites W2074485330 @default.
• W2410046771 cites W2088303670 @default.
• W2410046771 cites W2097784684 @default.
• W2410046771 cites W2101082168 @default.
• W2410046771 cites W2104564828 @default.
• W2410046771 cites W2108058966 @default.
• W2410046771 cites W2112705133 @default.
• W2410046771 cites W2118202340 @default.
• W2410046771 cites W2118720215 @default.
• W2410046771 cites W2119284085 @default.
• W2410046771 cites W2124305814 @default.
• W2410046771 cites W2126450798 @default.
• W2410046771 cites W2127407003 @default.
• W2410046771 cites W2134976660 @default.
• W2410046771 cites W2135172174 @default.
• W2410046771 cites W2141451936 @default.
• W2410046771 cites W2148332776 @default.
• W2410046771 cites W2160448685 @default.
• W2410046771 cites W2162793478 @default.
• W2410046771 cites W2316039752 @default.
• W2410046771 cites W2316313184 @default.
• W2410046771 cites W2324347180 @default.
• W2410046771 cites W2324637511 @default.
• W2410046771 cites W2325748680 @default.
• W2410046771 cites W2325965341 @default.
• W2410046771 cites W2401587733 @default.
• W2410046771 cites W2952670656 @default.
• W2410046771 cites W4243467985 @default.
• W2410046771 doi "https://doi.org/10.1021/acsnano.5b03923" @default.
• W2410046771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4826734" @default.
• W2410046771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26563913" @default.
• W2410046771 hasPublicationYear "2015" @default.
• W2410046771 type Work @default.
• W2410046771 sameAs 2410046771 @default.
• W2410046771 citedByCount "28" @default.
• W2410046771 countsByYear W24100467712016 @default.
• W2410046771 countsByYear W24100467712017 @default.
• W2410046771 countsByYear W24100467712018 @default.
• W2410046771 countsByYear W24100467712019 @default.
• W2410046771 countsByYear W24100467712020 @default.
• W2410046771 countsByYear W24100467712021 @default.
• W2410046771 countsByYear W24100467712022 @default.
• W2410046771 countsByYear W24100467712023 @default.
• W2410046771 crossrefType "journal-article" @default.
• W2410046771 hasAuthorship W2410046771A5013602438 @default.
• W2410046771 hasAuthorship W2410046771A5021414632 @default.
• W2410046771 hasAuthorship W2410046771A5039374362 @default.
• W2410046771 hasAuthorship W2410046771A5042859426 @default.
• W2410046771 hasAuthorship W2410046771A5079033224 @default.
• W2410046771 hasAuthorship W2410046771A5080903560 @default.
• W2410046771 hasBestOaLocation W24100467712 @default.
• W2410046771 hasConcept C104317684 @default.
• W2410046771 hasConcept C12554922 @default.
• W2410046771 hasConcept C126513998 @default.
• W2410046771 hasConcept C141795571 @default.
• W2410046771 hasConcept C171250308 @default.
• W2410046771 hasConcept C174319367 @default.
• W2410046771 hasConcept C185581394 @default.

• next