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- W2410083381 abstract "Idiopathic pure red-cell aplasia was successfully treated by high-dose intravenous immunoglobulin infusions (HDivIg) in 2 patients; 1 of these patients was refractory to other immunosuppressive drugs. We have observed responses to this therapy also in 3 of 5 patients--without pretreatment--with severe aplastic anemia. HDivIg treatment had no significant side effects; patients with aplastic syndromes could be treated as outpatients. Patients responding to HDivIg demonstrated different response patterns to ciclosporin A. Sequential treatment of aplastic syndromes with high-dose prednisone, HDivIg and ciclosporin A was effective in 6 of 7 patients. The results in this pilot study are comparable to those with other immunosuppressive strategies in patients with severe aplastic anemia who lack a bone marrow donor. Optimal dosage, sequence, and duration of this treatment modality remain to be defined." @default.
- W2410083381 created "2016-06-24" @default.
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- W2410083381 date "1993-04-01" @default.
- W2410083381 modified "2023-09-23" @default.
- W2410083381 title "[High-dose immunoglobulin therapy of aplastic syndrome]." @default.
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