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• W2410095089 abstract "Chemogenetic technologies, including the mutated human Gq-coupled M3 muscarinic receptor (hM3Dq), have greatly facilitated our ability to directly link changes in cellular activity to altered physiology and behavior. Here, we extend the hM3Dq toolkit with recombinase-responsive mouse lines that permit hM3Dq expression in virtually any cell type. These alleles encode a fusion protein designed to increase effective expression levels by concentrating hM3Dq to the cell body and dendrites. To illustrate their broad utility, we targeted three different genetically defined cell populations: noradrenergic neurons of the compact, bilateral locus coeruleus and two dispersed populations, Camk2a+ neurons and GFAP+ glia. In all three populations, we observed reproducible expression and confirmed that activation of hM3Dq is sufficient to dose-dependently evoke phenotypic changes, without extreme phenotypes associated with hM3Dq overexpression. These alleles offer the ability to non-invasively control activity of diverse cell types to uncover their function and dysfunction at any developmental stage." @default.
• W2410095089 created "2016-06-24" @default.
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• W2410095089 date "2016-06-01" @default.
• W2410095089 modified "2023-10-16" @default.
• W2410095089 title "Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types" @default.
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• W2410095089 doi "https://doi.org/10.1016/j.celrep.2016.05.034" @default.
• W2410095089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4915594" @default.
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