Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410134051> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2410134051 endingPage "32" @default.
- W2410134051 startingPage "23" @default.
- W2410134051 abstract "Effects of cis-diamminedichloroplatinum (cisplatin) on rat kidney were investigated. Clinical parameters in rat urine and blood were studied. Blood urea nitrogen (BUN) and creatinine in blood and K+ in urine increased, but Na+ in urine decreased. Contents of total P450 and metabolic activities towards lauric acid and arachidonic acid in rat renal microsomes were not changed by cisplatin treatment. The levels of P450 isozymes (CYP4A1, 4A2, 4A8 and 2C23) were determined in rat renal microsomes by immunoblotting. The levels of CYP4A2 and 4A8 which are lauric acid omega-hydroxylases were not changed, but the levels of CYP2C23 and 4A1 were increased significantly by cisplatin treatment. Effects of clofibrate, a typical inducer for CYP4A1, on rat kidney were compared with those of cisplatin. Clofibrate induced palmitoyl CoA oxidase (a marker enzyme of peroxysome), CYP4A1, and CYP4A2 and reduced triglyceride level in plasma. Cisplatin had similar effects to clofibrate and induced peroxysomes as well as CYP4A1, although the effects were at a lesser extent than those of clofibrate. The induction levels of CYP4A1 correlated with increased levels of BUN. The present findings suggest that induction of P450 by cisplatin may take part in the renal injury or nephrotoxicity of cisplatin." @default.
- W2410134051 created "2016-06-24" @default.
- W2410134051 creator A5011656487 @default.
- W2410134051 creator A5020339927 @default.
- W2410134051 creator A5036137017 @default.
- W2410134051 creator A5045181951 @default.
- W2410134051 creator A5085750226 @default.
- W2410134051 date "1998-01-01" @default.
- W2410134051 modified "2023-09-29" @default.
- W2410134051 title "cis-Diamminedichloroplatinum induces peroxisomes as well as CYP4A1 in rat kidney." @default.
- W2410134051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9523352" @default.
- W2410134051 hasPublicationYear "1998" @default.
- W2410134051 type Work @default.
- W2410134051 sameAs 2410134051 @default.
- W2410134051 citedByCount "1" @default.
- W2410134051 countsByYear W24101340512015 @default.
- W2410134051 crossrefType "journal-article" @default.
- W2410134051 hasAuthorship W2410134051A5011656487 @default.
- W2410134051 hasAuthorship W2410134051A5020339927 @default.
- W2410134051 hasAuthorship W2410134051A5036137017 @default.
- W2410134051 hasAuthorship W2410134051A5045181951 @default.
- W2410134051 hasAuthorship W2410134051A5085750226 @default.
- W2410134051 hasConcept C126189478 @default.
- W2410134051 hasConcept C126322002 @default.
- W2410134051 hasConcept C134018914 @default.
- W2410134051 hasConcept C181199279 @default.
- W2410134051 hasConcept C185592680 @default.
- W2410134051 hasConcept C2776694085 @default.
- W2410134051 hasConcept C2778078955 @default.
- W2410134051 hasConcept C2778176769 @default.
- W2410134051 hasConcept C2778239845 @default.
- W2410134051 hasConcept C2779496979 @default.
- W2410134051 hasConcept C2780026642 @default.
- W2410134051 hasConcept C2780091579 @default.
- W2410134051 hasConcept C2780306776 @default.
- W2410134051 hasConcept C55493867 @default.
- W2410134051 hasConcept C71924100 @default.
- W2410134051 hasConcept C86803240 @default.
- W2410134051 hasConcept C87644729 @default.
- W2410134051 hasConceptScore W2410134051C126189478 @default.
- W2410134051 hasConceptScore W2410134051C126322002 @default.
- W2410134051 hasConceptScore W2410134051C134018914 @default.
- W2410134051 hasConceptScore W2410134051C181199279 @default.
- W2410134051 hasConceptScore W2410134051C185592680 @default.
- W2410134051 hasConceptScore W2410134051C2776694085 @default.
- W2410134051 hasConceptScore W2410134051C2778078955 @default.
- W2410134051 hasConceptScore W2410134051C2778176769 @default.
- W2410134051 hasConceptScore W2410134051C2778239845 @default.
- W2410134051 hasConceptScore W2410134051C2779496979 @default.
- W2410134051 hasConceptScore W2410134051C2780026642 @default.
- W2410134051 hasConceptScore W2410134051C2780091579 @default.
- W2410134051 hasConceptScore W2410134051C2780306776 @default.
- W2410134051 hasConceptScore W2410134051C55493867 @default.
- W2410134051 hasConceptScore W2410134051C71924100 @default.
- W2410134051 hasConceptScore W2410134051C86803240 @default.
- W2410134051 hasConceptScore W2410134051C87644729 @default.
- W2410134051 hasIssue "1" @default.
- W2410134051 hasLocation W24101340511 @default.
- W2410134051 hasOpenAccess W2410134051 @default.
- W2410134051 hasPrimaryLocation W24101340511 @default.
- W2410134051 hasRelatedWork W1536669049 @default.
- W2410134051 hasRelatedWork W1966650116 @default.
- W2410134051 hasRelatedWork W1978758335 @default.
- W2410134051 hasRelatedWork W2145867958 @default.
- W2410134051 hasRelatedWork W2155342874 @default.
- W2410134051 hasRelatedWork W2197507768 @default.
- W2410134051 hasRelatedWork W2410134051 @default.
- W2410134051 hasRelatedWork W2769277866 @default.
- W2410134051 hasRelatedWork W2888911731 @default.
- W2410134051 hasRelatedWork W2529449964 @default.
- W2410134051 hasVolume "99" @default.
- W2410134051 isParatext "false" @default.
- W2410134051 isRetracted "false" @default.
- W2410134051 magId "2410134051" @default.
- W2410134051 workType "article" @default.