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• W2410146218 startingPage "6545" @default.
• W2410146218 abstract "The bromonucleosides (BrdX's) 5-bromo-2'-deoxyuridine (BrdU), 5-bromo-2'-deoxycytidine (BrdC), 8-bromo-2'-deoxyadenosine (BrdA), and 5-bromo-2'-deoxyguanosine (BrdG) may substitute for ordinary nucleosides in DNA. As indicated by electron-stimulated desorption experiments, such a modified biopolymer is greater than 2-3-fold more sensitive to damage induced by excess electrons. The other major product of water radiolysis, the (•)OH radical, may form a number of other radicals in chemical reactions with the complex content of the cell. Thus, the well-proved BrdU-labeled DNA radiosensitivity may be, at least in part, related to secondary organic radicals. Therefore, in the current study, the propensity of BrdX's to damage induced by 2-hydroxypropyl radical (OHisop(•))-a prototype radical species-was investigated. The HPLC and LC-MS analyses revealed the formation of two major products from the brominated pyrimidine nucleosides, a native nucleoside and an adduct of BrdX and OHisop(•) , and only an adduct of BrdX from the bromopurine nucleosides. Quantum chemical calculations ascribed this evident difference between purines and pyrimidines to the electron transfer from OHisop(•) to BrdX that is especially favorable in pyrimidines." @default.
• W2410146218 created "2016-06-24" @default.
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• W2410146218 date "2015-05-26" @default.
• W2410146218 modified "2023-10-16" @default.
• W2410146218 title "Reactivity Pattern of Bromonucleosides Induced by 2-Hydroxypropyl Radicals: Photochemical, Radiation Chemical, and Computational Studies" @default.
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• W2410146218 doi "https://doi.org/10.1021/acs.jpcb.5b01904" @default.
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• W2410146218 hasPublicationYear "2015" @default.
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