Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410162015> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2410162015 endingPage "387" @default.
- W2410162015 startingPage "383" @default.
- W2410162015 abstract "Summary Hybridoma cells were produced by fusing mouse myeloma cells (SP 2/0 - Ag 14) with spleen cells from a Balb/c mouse, previously immunized with the partially purified complex between tissue plasminogen activator (t-PA) and its fast inhibitor from human plasma (serum). Screening with a radioimmunoassay revealed a number of hybridomas secreting antibodies directed towards the complex. Of these, about 1/3 reacted both with the complex and t-PA, whereas about 2/3 reacted only with the complex. Three of the latter hybridomas, producing antibodies directed towards the inhibitor-moiety in the complex have been cloned and the antibodies were studied in detail. PA-inhibitor activity in plasma or serum and t-PA/PA-inhibitor complex could be specifically adsorbed on all three insolubilized monoclonal antibodies (MCI, MC2 and MC3). None of the antibodies seems to be directed against structures of vital importance for the functional activity of the PA-inhibitor. In accordance with this finding the antibody with the highest avidity (MCI) reacts equally well with the PA-inhibitor alone or in complex with t-PA. A radioimmunoassay was devloped with this antibody and significant displacement was obtained with samples with PA-inhibitor concentrations above 2 AU/mL. In 13 plasma samples with different levels of PA-inhibitory activity a significant correlation was obtained when comparing this activity with the PA-inhibitor antigen as measured with the radioimmunoassay (r = 0.88)." @default.
- W2410162015 created "2016-06-24" @default.
- W2410162015 creator A5000655461 @default.
- W2410162015 creator A5016504353 @default.
- W2410162015 creator A5020438126 @default.
- W2410162015 creator A5024944801 @default.
- W2410162015 creator A5086877550 @default.
- W2410162015 date "1986-01-01" @default.
- W2410162015 modified "2023-10-03" @default.
- W2410162015 title "Monoclonal Antibodies Towards the Fast Inhibitor of Tissue Plasminogen Activator from Human Plasma and Serum" @default.
- W2410162015 doi "https://doi.org/10.1055/s-0038-1661569" @default.
- W2410162015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3092395" @default.
- W2410162015 hasPublicationYear "1986" @default.
- W2410162015 type Work @default.
- W2410162015 sameAs 2410162015 @default.
- W2410162015 citedByCount "10" @default.
- W2410162015 crossrefType "journal-article" @default.
- W2410162015 hasAuthorship W2410162015A5000655461 @default.
- W2410162015 hasAuthorship W2410162015A5016504353 @default.
- W2410162015 hasAuthorship W2410162015A5020438126 @default.
- W2410162015 hasAuthorship W2410162015A5024944801 @default.
- W2410162015 hasAuthorship W2410162015A5086877550 @default.
- W2410162015 hasConcept C134018914 @default.
- W2410162015 hasConcept C147483822 @default.
- W2410162015 hasConcept C153911025 @default.
- W2410162015 hasConcept C159654299 @default.
- W2410162015 hasConcept C163864487 @default.
- W2410162015 hasConcept C176685330 @default.
- W2410162015 hasConcept C185592680 @default.
- W2410162015 hasConcept C203014093 @default.
- W2410162015 hasConcept C2779679481 @default.
- W2410162015 hasConcept C2780675426 @default.
- W2410162015 hasConcept C542903549 @default.
- W2410162015 hasConcept C55493867 @default.
- W2410162015 hasConcept C86803240 @default.
- W2410162015 hasConceptScore W2410162015C134018914 @default.
- W2410162015 hasConceptScore W2410162015C147483822 @default.
- W2410162015 hasConceptScore W2410162015C153911025 @default.
- W2410162015 hasConceptScore W2410162015C159654299 @default.
- W2410162015 hasConceptScore W2410162015C163864487 @default.
- W2410162015 hasConceptScore W2410162015C176685330 @default.
- W2410162015 hasConceptScore W2410162015C185592680 @default.
- W2410162015 hasConceptScore W2410162015C203014093 @default.
- W2410162015 hasConceptScore W2410162015C2779679481 @default.
- W2410162015 hasConceptScore W2410162015C2780675426 @default.
- W2410162015 hasConceptScore W2410162015C542903549 @default.
- W2410162015 hasConceptScore W2410162015C55493867 @default.
- W2410162015 hasConceptScore W2410162015C86803240 @default.
- W2410162015 hasIssue "03" @default.
- W2410162015 hasLocation W24101620151 @default.
- W2410162015 hasLocation W24101620152 @default.
- W2410162015 hasOpenAccess W2410162015 @default.
- W2410162015 hasPrimaryLocation W24101620151 @default.
- W2410162015 hasRelatedWork W1602847563 @default.
- W2410162015 hasRelatedWork W1951050634 @default.
- W2410162015 hasRelatedWork W1968850107 @default.
- W2410162015 hasRelatedWork W1992169430 @default.
- W2410162015 hasRelatedWork W1998831848 @default.
- W2410162015 hasRelatedWork W2037509311 @default.
- W2410162015 hasRelatedWork W2038126255 @default.
- W2410162015 hasRelatedWork W2073262237 @default.
- W2410162015 hasRelatedWork W2146940419 @default.
- W2410162015 hasRelatedWork W2409634333 @default.
- W2410162015 hasVolume "55" @default.
- W2410162015 isParatext "false" @default.
- W2410162015 isRetracted "false" @default.
- W2410162015 magId "2410162015" @default.
- W2410162015 workType "article" @default.