Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410197761> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2410197761 endingPage "5" @default.
- W2410197761 startingPage "411" @default.
- W2410197761 abstract "Gonadotropin-releasing hormone (GnRH) analogs and antiestrogens display direct antiestrogenic effects on the proliferation of hormone-sensitive breast cancer cells. This study aimed to determine whether growth inhibition of 17 beta-estradiol-stimulated MCF-7 breast cancer cells by the agonist D-Trp6 GnRH, the GnRH antagonist BIM 21009C and 4-hydroxy-tamoxifen (OHT) respectively occurred through alterations of the estrogen receptor (ER)-mediated intracellular pathway. The pS2 mRNA expression is primarily dependent on activated ER in MCF-7 cells, and pS2 protein could act as a growth factor. Drug effect on pS2 mRNAs were qualitatively compared to those on the cell cycle. Unlike OHT, GnRH analogs did not suppress the 17 beta-estradiol-induced pS2 mRNA expression whilst the cell cycle was blocked. The pS2 mRNA expression was induced by D-Trp6 GnRH alone without effect on the cell cycle. The outcome of our study is double. Firstly, GnRH analogs are distinct from OHT as regards their effects on the ER-mediated intracellular pathway. Secondly, pS2 mRNA expression is not strictly related to MCF-7 cell proliferation, suggesting that pS2 protein has a function other than that of critical growth regulator." @default.
- W2410197761 created "2016-06-24" @default.
- W2410197761 creator A5026117716 @default.
- W2410197761 creator A5041949824 @default.
- W2410197761 creator A5049427388 @default.
- W2410197761 creator A5066978149 @default.
- W2410197761 date "1991-01-01" @default.
- W2410197761 modified "2023-09-23" @default.
- W2410197761 title "Distinct effects of gonadotropin-releasing hormone analogs and 4-hydroxytamoxifen on pS2 mRNA expression with respect to cell proliferation in MCF-7 breast cancer cells." @default.
- W2410197761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1826824" @default.
- W2410197761 hasPublicationYear "1991" @default.
- W2410197761 type Work @default.
- W2410197761 sameAs 2410197761 @default.
- W2410197761 citedByCount "4" @default.
- W2410197761 crossrefType "journal-article" @default.
- W2410197761 hasAuthorship W2410197761A5026117716 @default.
- W2410197761 hasAuthorship W2410197761A5041949824 @default.
- W2410197761 hasAuthorship W2410197761A5049427388 @default.
- W2410197761 hasAuthorship W2410197761A5066978149 @default.
- W2410197761 hasConcept C104317684 @default.
- W2410197761 hasConcept C105580179 @default.
- W2410197761 hasConcept C109541995 @default.
- W2410197761 hasConcept C121608353 @default.
- W2410197761 hasConcept C126322002 @default.
- W2410197761 hasConcept C134018914 @default.
- W2410197761 hasConcept C2776067312 @default.
- W2410197761 hasConcept C2777164284 @default.
- W2410197761 hasConcept C2777176818 @default.
- W2410197761 hasConcept C2778575703 @default.
- W2410197761 hasConcept C2778894405 @default.
- W2410197761 hasConcept C29537977 @default.
- W2410197761 hasConcept C2994423619 @default.
- W2410197761 hasConcept C502942594 @default.
- W2410197761 hasConcept C530470458 @default.
- W2410197761 hasConcept C55493867 @default.
- W2410197761 hasConcept C62112901 @default.
- W2410197761 hasConcept C71315377 @default.
- W2410197761 hasConcept C71924100 @default.
- W2410197761 hasConcept C79879829 @default.
- W2410197761 hasConcept C84606932 @default.
- W2410197761 hasConcept C86803240 @default.
- W2410197761 hasConcept C95444343 @default.
- W2410197761 hasConcept C96232424 @default.
- W2410197761 hasConceptScore W2410197761C104317684 @default.
- W2410197761 hasConceptScore W2410197761C105580179 @default.
- W2410197761 hasConceptScore W2410197761C109541995 @default.
- W2410197761 hasConceptScore W2410197761C121608353 @default.
- W2410197761 hasConceptScore W2410197761C126322002 @default.
- W2410197761 hasConceptScore W2410197761C134018914 @default.
- W2410197761 hasConceptScore W2410197761C2776067312 @default.
- W2410197761 hasConceptScore W2410197761C2777164284 @default.
- W2410197761 hasConceptScore W2410197761C2777176818 @default.
- W2410197761 hasConceptScore W2410197761C2778575703 @default.
- W2410197761 hasConceptScore W2410197761C2778894405 @default.
- W2410197761 hasConceptScore W2410197761C29537977 @default.
- W2410197761 hasConceptScore W2410197761C2994423619 @default.
- W2410197761 hasConceptScore W2410197761C502942594 @default.
- W2410197761 hasConceptScore W2410197761C530470458 @default.
- W2410197761 hasConceptScore W2410197761C55493867 @default.
- W2410197761 hasConceptScore W2410197761C62112901 @default.
- W2410197761 hasConceptScore W2410197761C71315377 @default.
- W2410197761 hasConceptScore W2410197761C71924100 @default.
- W2410197761 hasConceptScore W2410197761C79879829 @default.
- W2410197761 hasConceptScore W2410197761C84606932 @default.
- W2410197761 hasConceptScore W2410197761C86803240 @default.
- W2410197761 hasConceptScore W2410197761C95444343 @default.
- W2410197761 hasConceptScore W2410197761C96232424 @default.
- W2410197761 hasIssue "1" @default.
- W2410197761 hasLocation W24101977611 @default.
- W2410197761 hasOpenAccess W2410197761 @default.
- W2410197761 hasPrimaryLocation W24101977611 @default.
- W2410197761 hasRelatedWork W1536362773 @default.
- W2410197761 hasRelatedWork W2025170339 @default.
- W2410197761 hasRelatedWork W2033623925 @default.
- W2410197761 hasRelatedWork W2053656289 @default.
- W2410197761 hasRelatedWork W2058549491 @default.
- W2410197761 hasRelatedWork W2062688712 @default.
- W2410197761 hasRelatedWork W2088975813 @default.
- W2410197761 hasRelatedWork W2158521225 @default.
- W2410197761 hasRelatedWork W2167042538 @default.
- W2410197761 hasRelatedWork W2410109119 @default.
- W2410197761 hasVolume "11" @default.
- W2410197761 isParatext "false" @default.
- W2410197761 isRetracted "false" @default.
- W2410197761 magId "2410197761" @default.
- W2410197761 workType "article" @default.