Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410258802> ?p ?o ?g. }
- W2410258802 endingPage "669" @default.
- W2410258802 startingPage "657" @default.
- W2410258802 abstract "The epidermal growth factor receptor (EGFR) is a promising target for anti-cancer therapy. The aim of this study was to design thermosensitive liposomes (TSL), functionalized with anti-EGFR ligands for targeted delivery and localized triggered release of chemotherapy. For targeting, EGFR specific peptide (GE11) and Fab⿲ fragments of cetuximab were used and the effect of ligand density on in vitro tumor targeting was investigated. Ligand conjugation did not significantly change the physicochemical characteristics of liposomes. Fab⿲-decorated TSL (Fab⿲-TSL) can specifically and more efficiently bind to the EGFR overexpressed cancer cells as compared to GE11 modified TSL. Calcein labeled Fab⿲-TSL showed adequate stability at 37 °C in serum (<4% calcein released after 1 h) and a temperature dependent release at above 40 °C. FACS analysis and live cell imaging showed efficient and EGFR mediated cellular association as well as dramatic intracellular cargo release upon hyperthermia. Fab⿲-conjugation and hyperthermia induced enhanced tumor cell cytotoxicity of doxorubicin loaded TSL. The relative cytotoxicity of Fab⿲-TSL was also correlated to EGFR density on the tumor cells. These results suggest that Fab⿲-TSL showed great potential for combinational targeted and triggered release drug delivery." @default.
- W2410258802 created "2016-06-24" @default.
- W2410258802 creator A5039741528 @default.
- W2410258802 creator A5041546307 @default.
- W2410258802 creator A5045847838 @default.
- W2410258802 creator A5085241723 @default.
- W2410258802 creator A5086931419 @default.
- W2410258802 date "2016-10-01" @default.
- W2410258802 modified "2023-10-18" @default.
- W2410258802 title "EGFR targeted thermosensitive liposomes: A novel multifunctional platform for simultaneous tumor targeted and stimulus responsive drug delivery" @default.
- W2410258802 cites W1498814102 @default.
- W2410258802 cites W1554880727 @default.
- W2410258802 cites W1973805295 @default.
- W2410258802 cites W1975785001 @default.
- W2410258802 cites W1978521258 @default.
- W2410258802 cites W1985239297 @default.
- W2410258802 cites W1986168443 @default.
- W2410258802 cites W1992228525 @default.
- W2410258802 cites W1993575340 @default.
- W2410258802 cites W1996366496 @default.
- W2410258802 cites W1999494701 @default.
- W2410258802 cites W2000568918 @default.
- W2410258802 cites W2003110090 @default.
- W2410258802 cites W2015137678 @default.
- W2410258802 cites W2015665955 @default.
- W2410258802 cites W2023660230 @default.
- W2410258802 cites W2025831531 @default.
- W2410258802 cites W2036903274 @default.
- W2410258802 cites W2046308571 @default.
- W2410258802 cites W2050715080 @default.
- W2410258802 cites W2052256056 @default.
- W2410258802 cites W2052668776 @default.
- W2410258802 cites W2062331230 @default.
- W2410258802 cites W2071940088 @default.
- W2410258802 cites W2076226743 @default.
- W2410258802 cites W2078228909 @default.
- W2410258802 cites W2078278161 @default.
- W2410258802 cites W2079511147 @default.
- W2410258802 cites W2079736261 @default.
- W2410258802 cites W2081477031 @default.
- W2410258802 cites W2088333494 @default.
- W2410258802 cites W2102131116 @default.
- W2410258802 cites W2104263066 @default.
- W2410258802 cites W2143779949 @default.
- W2410258802 cites W2157337500 @default.
- W2410258802 cites W2162418835 @default.
- W2410258802 cites W2170726961 @default.
- W2410258802 cites W2322857556 @default.
- W2410258802 cites W2328157564 @default.
- W2410258802 cites W2329549912 @default.
- W2410258802 cites W2467809481 @default.
- W2410258802 cites W339838209 @default.
- W2410258802 doi "https://doi.org/10.1016/j.colsurfb.2016.06.012" @default.
- W2410258802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27434152" @default.
- W2410258802 hasPublicationYear "2016" @default.
- W2410258802 type Work @default.
- W2410258802 sameAs 2410258802 @default.
- W2410258802 citedByCount "39" @default.
- W2410258802 countsByYear W24102588022017 @default.
- W2410258802 countsByYear W24102588022018 @default.
- W2410258802 countsByYear W24102588022019 @default.
- W2410258802 countsByYear W24102588022020 @default.
- W2410258802 countsByYear W24102588022021 @default.
- W2410258802 countsByYear W24102588022022 @default.
- W2410258802 countsByYear W24102588022023 @default.
- W2410258802 crossrefType "journal-article" @default.
- W2410258802 hasAuthorship W2410258802A5039741528 @default.
- W2410258802 hasAuthorship W2410258802A5041546307 @default.
- W2410258802 hasAuthorship W2410258802A5045847838 @default.
- W2410258802 hasAuthorship W2410258802A5085241723 @default.
- W2410258802 hasAuthorship W2410258802A5086931419 @default.
- W2410258802 hasConcept C109316439 @default.
- W2410258802 hasConcept C126511603 @default.
- W2410258802 hasConcept C141071460 @default.
- W2410258802 hasConcept C159654299 @default.
- W2410258802 hasConcept C170493617 @default.
- W2410258802 hasConcept C178790620 @default.
- W2410258802 hasConcept C185154212 @default.
- W2410258802 hasConcept C185592680 @default.
- W2410258802 hasConcept C202751555 @default.
- W2410258802 hasConcept C203014093 @default.
- W2410258802 hasConcept C2776694085 @default.
- W2410258802 hasConcept C2776872141 @default.
- W2410258802 hasConcept C2779438470 @default.
- W2410258802 hasConcept C2779820397 @default.
- W2410258802 hasConcept C2779998722 @default.
- W2410258802 hasConcept C2781303535 @default.
- W2410258802 hasConcept C41625074 @default.
- W2410258802 hasConcept C502942594 @default.
- W2410258802 hasConcept C542903549 @default.
- W2410258802 hasConcept C55493867 @default.
- W2410258802 hasConcept C71924100 @default.
- W2410258802 hasConcept C98274493 @default.
- W2410258802 hasConceptScore W2410258802C109316439 @default.
- W2410258802 hasConceptScore W2410258802C126511603 @default.
- W2410258802 hasConceptScore W2410258802C141071460 @default.
- W2410258802 hasConceptScore W2410258802C159654299 @default.
- W2410258802 hasConceptScore W2410258802C170493617 @default.