FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410260045> ?p ?o ?g. }

• W2410260045 endingPage "42392" @default.
• W2410260045 startingPage "42385" @default.
• W2410260045 abstract "Oncogenic mutations in the gene KRAS are commonly detected in non-small cell lung cancer (NSCLC). This disease is inherently difficult to treat, and combinations involving platinum-based drugs remain the therapeutic mainstay. In terms of novel, pharmacologically actionable targets, nitric oxide synthases (NOS) have been implicated in the etiology of KRAS-driven cancers, including lung cancer, and small molecular weight NOS inhibitors have been developed for the treatment of other diseases. Thus, we evaluated the anti-neoplastic activity of the oral NOS inhibitor L-NAME in a randomized preclinical trial using a genetically engineered mouse model of Kras and p53 mutation-positive NSCLC. We report here that L-NAME decreased lung tumor growth in vivo, as assessed by sequential radiological imaging, and provided a survival advantage, perhaps the most difficult clinical parameter to improve upon. Moreover, L-NAME enhanced the therapeutic benefit afforded by carboplatin chemotherapy, provided it was administered as maintenance therapy after carboplatin. Collectively, these results support the clinical evaluation of L-NAME for the treatment of KRAS mutation-positive NSCLC." @default.
• W2410260045 created "2016-06-24" @default.
• W2410260045 creator A5017614420 @default.
• W2410260045 creator A5063852242 @default.
• W2410260045 creator A5077289692 @default.
• W2410260045 creator A5087099776 @default.
• W2410260045 date "2016-06-07" @default.
• W2410260045 modified "2023-09-26" @default.
• W2410260045 title "Treatment with the nitric oxide synthase inhibitor L-NAME provides a survival advantage in a mouse model of <i>Kras</i> mutation-positive, non-small cell lung cancer" @default.
• W2410260045 cites W1487052925 @default.
• W2410260045 cites W1647872836 @default.
• W2410260045 cites W1848316250 @default.
• W2410260045 cites W1976088762 @default.
• W2410260045 cites W1977863137 @default.
• W2410260045 cites W1981537761 @default.
• W2410260045 cites W1982488143 @default.
• W2410260045 cites W1983965827 @default.
• W2410260045 cites W1994772304 @default.
• W2410260045 cites W1997807898 @default.
• W2410260045 cites W2012084975 @default.
• W2410260045 cites W2020242649 @default.
• W2410260045 cites W2020423449 @default.
• W2410260045 cites W2026838423 @default.
• W2410260045 cites W2036733146 @default.
• W2410260045 cites W2063053685 @default.
• W2410260045 cites W2064174415 @default.
• W2410260045 cites W2066166336 @default.
• W2410260045 cites W2068933269 @default.
• W2410260045 cites W2079037244 @default.
• W2410260045 cites W2089986662 @default.
• W2410260045 cites W2090458427 @default.
• W2410260045 cites W2090944178 @default.
• W2410260045 cites W2091193879 @default.
• W2410260045 cites W2091455299 @default.
• W2410260045 cites W2091499945 @default.
• W2410260045 cites W2097571046 @default.
• W2410260045 cites W2105820269 @default.
• W2410260045 cites W2107665428 @default.
• W2410260045 cites W2115153703 @default.
• W2410260045 cites W2116003704 @default.
• W2410260045 cites W2127819670 @default.
• W2410260045 cites W2134304491 @default.
• W2410260045 cites W2140789107 @default.
• W2410260045 cites W2157905789 @default.
• W2410260045 cites W2161869976 @default.
• W2410260045 cites W2162337307 @default.
• W2410260045 cites W2163780874 @default.
• W2410260045 cites W2269700560 @default.
• W2410260045 cites W2432861178 @default.
• W2410260045 cites W2470264751 @default.
• W2410260045 cites W2560367415 @default.
• W2410260045 cites W2566863750 @default.
• W2410260045 cites W2572174216 @default.
• W2410260045 cites W2738996050 @default.
• W2410260045 cites W4234401654 @default.
• W2410260045 cites W4239714259 @default.
• W2410260045 cites W4297939389 @default.
• W2410260045 doi "https://doi.org/10.18632/oncotarget.9874" @default.
• W2410260045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5173142" @default.
• W2410260045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27285753" @default.
• W2410260045 hasPublicationYear "2016" @default.
• W2410260045 type Work @default.
• W2410260045 sameAs 2410260045 @default.
• W2410260045 citedByCount "15" @default.
• W2410260045 countsByYear W24102600452017 @default.
• W2410260045 countsByYear W24102600452018 @default.
• W2410260045 countsByYear W24102600452019 @default.
• W2410260045 countsByYear W24102600452020 @default.
• W2410260045 countsByYear W24102600452021 @default.
• W2410260045 countsByYear W24102600452022 @default.
• W2410260045 crossrefType "journal-article" @default.
• W2410260045 hasAuthorship W2410260045A5017614420 @default.
• W2410260045 hasAuthorship W2410260045A5063852242 @default.
• W2410260045 hasAuthorship W2410260045A5077289692 @default.
• W2410260045 hasAuthorship W2410260045A5087099776 @default.
• W2410260045 hasBestOaLocation W24102600451 @default.
• W2410260045 hasConcept C121608353 @default.
• W2410260045 hasConcept C126322002 @default.
• W2410260045 hasConcept C143998085 @default.
• W2410260045 hasConcept C2776256026 @default.
• W2410260045 hasConcept C2776694085 @default.
• W2410260045 hasConcept C2778239845 @default.
• W2410260045 hasConcept C2781187634 @default.
• W2410260045 hasConcept C2781451048 @default.
• W2410260045 hasConcept C502942594 @default.
• W2410260045 hasConcept C526805850 @default.
• W2410260045 hasConcept C71924100 @default.
• W2410260045 hasConceptScore W2410260045C121608353 @default.
• W2410260045 hasConceptScore W2410260045C126322002 @default.
• W2410260045 hasConceptScore W2410260045C143998085 @default.
• W2410260045 hasConceptScore W2410260045C2776256026 @default.
• W2410260045 hasConceptScore W2410260045C2776694085 @default.
• W2410260045 hasConceptScore W2410260045C2778239845 @default.
• W2410260045 hasConceptScore W2410260045C2781187634 @default.
• W2410260045 hasConceptScore W2410260045C2781451048 @default.
• W2410260045 hasConceptScore W2410260045C502942594 @default.
• W2410260045 hasConceptScore W2410260045C526805850 @default.
• W2410260045 hasConceptScore W2410260045C71924100 @default.

• next