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- W2410273855 startingPage "155" @default.
- W2410273855 abstract "Family studies have consistently shown that Tourette syndrome (TS) is a familial disorder and twin studies have clearly indicated a genetic contribution in the etiology of TS. Whereas early segregation studies of TS suggested a single-gene autosomal dominant disorder, later studies have pointed to more complex models including additive and multifactorial inheritance and likely interaction with genetic factors. While the exact cellular and molecular base of TS is as yet elusive, neuroanatomical and neurophysiological studies have pointed to the involvement of cortico-striato-thalamocortical circuits and abnormalities in dopamine, glutamate, gamma-aminobutyric acid, and serotonin neurotransmitter systems, with the most consistent evidence being available for involvement of dopamine-related abnormalities, that is, a reduction in tonic extracellular dopamine levels along with hyperresponsive spike-dependent dopamine release, following stimulation. Genetic and gene expression findings are very much supportive of involvement of these neurotransmitter systems. Moreover, intriguingly, genetic work on a two-generation pedigree has opened new research pointing to a role for histamine, a so far rather neglected neurotransmitter, with the potential of the development of new treatment options. Future studies should be aimed at directly linking neurotransmitter-related genetic and gene expression findings to imaging studies (imaging genetics), which enables a better understanding of the pathways and mechanisms through which the dynamic interplay of genes, brain, and environment shapes the TS phenotype." @default.
- W2410273855 created "2016-06-24" @default.
- W2410273855 creator A5021502220 @default.
- W2410273855 creator A5033788029 @default.
- W2410273855 creator A5039262584 @default.
- W2410273855 creator A5039838663 @default.
- W2410273855 creator A5067478725 @default.
- W2410273855 date "2013-01-01" @default.
- W2410273855 modified "2023-10-11" @default.
- W2410273855 title "Genetic Susceptibility and Neurotransmitters in Tourette Syndrome" @default.
- W2410273855 cites W1495420103 @default.
- W2410273855 cites W1528547292 @default.
- W2410273855 cites W1601979337 @default.
- W2410273855 cites W1710014040 @default.
- W2410273855 cites W1902737401 @default.
- W2410273855 cites W1968042434 @default.
- W2410273855 cites W1969420903 @default.
- W2410273855 cites W1971250615 @default.
- W2410273855 cites W1972840565 @default.
- W2410273855 cites W1974467112 @default.
- W2410273855 cites W1976114760 @default.
- W2410273855 cites W1978881126 @default.
- W2410273855 cites W1982522250 @default.
- W2410273855 cites W1984772239 @default.
- W2410273855 cites W1986531447 @default.
- W2410273855 cites W1988320696 @default.
- W2410273855 cites W1990107367 @default.
- W2410273855 cites W1995291346 @default.
- W2410273855 cites W1996951168 @default.
- W2410273855 cites W1997185781 @default.
- W2410273855 cites W1998247306 @default.
- W2410273855 cites W1998618539 @default.
- W2410273855 cites W1998752191 @default.
- W2410273855 cites W2003906114 @default.
- W2410273855 cites W2007489644 @default.
- W2410273855 cites W2010604180 @default.
- W2410273855 cites W2016864963 @default.
- W2410273855 cites W2021063855 @default.
- W2410273855 cites W2026525947 @default.
- W2410273855 cites W2028150011 @default.
- W2410273855 cites W2029766049 @default.
- W2410273855 cites W2031134758 @default.
- W2410273855 cites W2031959540 @default.
- W2410273855 cites W2034150569 @default.
- W2410273855 cites W2040547582 @default.
- W2410273855 cites W2041237576 @default.
- W2410273855 cites W2041405722 @default.
- W2410273855 cites W2045890024 @default.
- W2410273855 cites W2054642628 @default.
- W2410273855 cites W2055799496 @default.
- W2410273855 cites W2057120528 @default.
- W2410273855 cites W2059581034 @default.
- W2410273855 cites W2060355077 @default.
- W2410273855 cites W2061516597 @default.
- W2410273855 cites W2065570031 @default.
- W2410273855 cites W2068072276 @default.
- W2410273855 cites W2069105469 @default.
- W2410273855 cites W2069394078 @default.
- W2410273855 cites W2072624089 @default.
- W2410273855 cites W2074018083 @default.
- W2410273855 cites W2075825728 @default.
- W2410273855 cites W2079130139 @default.
- W2410273855 cites W2080914771 @default.
- W2410273855 cites W2081668545 @default.
- W2410273855 cites W2083878293 @default.
- W2410273855 cites W2083944558 @default.
- W2410273855 cites W2093193228 @default.
- W2410273855 cites W2094055942 @default.
- W2410273855 cites W2094366691 @default.
- W2410273855 cites W2095071039 @default.
- W2410273855 cites W2095933386 @default.
- W2410273855 cites W2098030978 @default.
- W2410273855 cites W2098258490 @default.
- W2410273855 cites W2098574165 @default.
- W2410273855 cites W2105548486 @default.
- W2410273855 cites W2106095564 @default.
- W2410273855 cites W2108369668 @default.
- W2410273855 cites W2110395878 @default.
- W2410273855 cites W2112696084 @default.
- W2410273855 cites W2118922889 @default.
- W2410273855 cites W2120360346 @default.
- W2410273855 cites W2122074197 @default.
- W2410273855 cites W2123035658 @default.
- W2410273855 cites W2131513978 @default.
- W2410273855 cites W2142890840 @default.
- W2410273855 cites W2143951357 @default.
- W2410273855 cites W2146300628 @default.
- W2410273855 cites W2146526204 @default.
- W2410273855 cites W2146643950 @default.
- W2410273855 cites W2147320841 @default.
- W2410273855 cites W2149813409 @default.
- W2410273855 cites W2153617058 @default.
- W2410273855 cites W2156162860 @default.
- W2410273855 cites W2157350684 @default.
- W2410273855 cites W2159909358 @default.
- W2410273855 cites W2161935988 @default.
- W2410273855 cites W2169757912 @default.
- W2410273855 cites W2170362840 @default.