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• W2410282547 abstract "Introduction: Osteoarthritis (OA) is the most common joint disease. Certain neuropeptides contribute to both the continuance of symptoms and cartilage damage resulting from the disease. Symptomatic drugs are frequently used for pain control, but dissatisfaction with such an intervention has led many patients to seek other treatments, 1 of which is thermal heat from mud packs. Our intentions in the present study were to investigate a possible interaction between thermal treatment and the main neuropeptides involved in OA pathogenesis and to identify any possible detrimental effect of heat application on OA joints. Materials and Methods: Forty-eight patients with lumbar OA were enrolled in the study and randomized to Group A (12 days of mud-pack treatment at 39-40° C plus thermal bath at 37°-38° C and 500 mg acetaminophen twice per day) or Group B (drug treatment only, 500 mg acetaminophen twice per day). Blood samples were collected for assays of gamma neuropeptide (γNP), calcitonin gene-related peptide (CGRP), substance P (SP), and beta nerve-growth factor (βNGF) . Results: Statistical analysis has shown a significant difference between baseline and final values of the measured parameters in both groups. In group A, all the samples showed a variation of the same sign as the mean. Evidence for a greater modification of baseline levels of CGRP and SP in Group A was obtained by statistical analysis. Discussion: Our data suggest that hot mud packs/thermal baths do not have a negative effect on OA patients. Heat treatment seems to increase the effect of pharmacological therapy on some neuropeptides involved in the pathogenesis of OA. Thus, it is possible that a combined therapy such as that used in Group A could be tried with the main antiinflammatory drugs used in OA in an effort to decrease dosages and increase the patients’ safety." @default.
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• W2410282547 date "2009-01-01" @default.
• W2410282547 modified "2023-09-27" @default.
• W2410282547 title "Modulation of Neurogenic Inflammation in Osteoarthrosis Patients Undergoing a Combined Treatment of Mud Packs, Thermal Baths, and Acetaminophen: A Preliminary Study" @default.
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