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- W2410286045 endingPage "126" @default.
- W2410286045 startingPage "126" @default.
- W2410286045 abstract "Hepatitis B virus (HBV) has a worldwide distribution and is endemic in many populations. Due to its unique life cycle which requires an error-prone reverse transcriptase for replication, it constantly evolves, resulting in tremendous genetic variation in the form of genotypes, sub-genotypes, and mutations. In recent years, there has been considerable research on the relationship between HBV genetic variation and HBV-related pathogenesis, which has profound implications in the natural history of HBV infection, viral detection, immune prevention, drug treatment and prognosis. In this review, we attempted to provide a brief account of the influence of HBV genotype on the pathogenesis of HBV infection and summarize our current knowledge on the effects of HBV mutations in different regions on HBV-associated pathogenesis, with an emphasis on mutations in the preS/S proteins in immune evasion, occult HBV infection and hepatocellular carcinoma (HCC), mutations in polymerase in relation to drug resistance, mutations in HBV core and e antigen in immune evasion, chronicalization of infection and hepatitis B-related acute-on-chronic liver failure, and finally mutations in HBV x proteins in HCC." @default.
- W2410286045 created "2016-06-24" @default.
- W2410286045 creator A5038002804 @default.
- W2410286045 creator A5043427543 @default.
- W2410286045 creator A5044825770 @default.
- W2410286045 creator A5048805901 @default.
- W2410286045 creator A5063783789 @default.
- W2410286045 creator A5083954692 @default.
- W2410286045 date "2016-01-01" @default.
- W2410286045 modified "2023-10-16" @default.
- W2410286045 title "Genetic variation of hepatitis B virus and its significance for pathogenesis" @default.
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