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- W2410311968 abstract "The synthesis of two fluorescent coumarin-type chiral derivatization agents (4 and 11) is reported. A chiral side chain was introduced at position 7 of the coumarin via Mitsunobu reaction. The two coumarins bear in this side chain either a free amino group or a carboxyl group, making them useful for further transformations. Conjugates of chiral prototype drugs with 4 or 11 were prepared by amide coupling of the analyte's carboxyl group to the reagent's amine group, or vice versa. The separation of seven diastereomeric conjugates through achiral high-performance liquid chromatography (HPLC) on a common C18 column is demonstrated." @default.
- W2410311968 created "2016-06-24" @default.
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- W2410311968 date "2013-10-23" @default.
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- W2410311968 title "Synthesis and Evaluation of Two Coumarin-Type Derivatization Reagents for Fluorescence Detection of Chiral Amines and Chiral Carboxylic Acids" @default.
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- W2410311968 doi "https://doi.org/10.1002/chir.22240" @default.
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