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• W2410344554 abstract "Circulating interleukin (IL)-6 concentrations are associated with endothelial activation in rheumatoid arthritis (RA).To assess endothelial activation before and after suppression of cytokine production in RA.Twenty-one patients (mean (SD) age 59 (9) years; disease duration 6 (4) years) were treated with intraarticular methylprednisolone acetate (417 (152) mg) together with disease modifying agent (DMARD) initiation (n = 10) or intensification (n = 11) employing methotrexate (n = 11), leflunomide (n = 8), minocyclin (n = 6) and sulphasalazine (n = 1). Disease activity, circulating cytokines (IL-1, tumor necrosis factor alpha (TNF-alpha) and IL-6) and biomarkers of endothelial activation (circulating vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1)) were evaluated before and 2 weeks after treatment.The intervention resulted in reductions in 8 disease activity markers (p < or = 0.002). Serum IL-6 concentrations decreased from 17 (2.9) to 4.9 (4.6) pg/ml (p = 0.0008). Serum IL-1 and TNF-alpha levels did not change (p > or = 0.4). Serum VCAM-1 concentrations decreased from 912 (402) to 752 (252) (p = 0.003), ICAM-1 from 398 (205) to 323 (179) (p = 0.04) and ELAM-1 from 68 (28) to 53 (25) (p = 0.02) pg/ml, respectively. Baseline rheumatoid factor titers were associated with reductions in VCAM-1 (r(s) = 0.481, p = 0.03). In multivariable regression models, decreases in circulating interleukin-6 concentrations were associated with reductions in VCAM-1 (p < 0.0001), ICAM-1 (p = 0.005) and ELAM-1 (p = 0.02) independent of changes in disease activity, weight and blood pressure.Our results suggest that suppression of circulating IL-6 concentrations attenuates atherogenesis in active RA." @default.
• W2410344554 created "2016-06-24" @default.
• W2410344554 creator A5024664860 @default.
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• W2410344554 date "2006-06-10" @default.
• W2410344554 modified "2023-10-06" @default.
• W2410344554 title "Suppression of circulating interleukin-6 concentrations is associated with decreased endothelial activation in rheumatoid arthritis." @default.
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• W2410344554 cites W1651651515 @default.
• W2410344554 cites W1750895917 @default.
• W2410344554 cites W1781391238 @default.
• W2410344554 cites W1891655359 @default.
• W2410344554 cites W1909853035 @default.
• W2410344554 cites W1965148671 @default.
• W2410344554 cites W1972919038 @default.
• W2410344554 cites W1980841695 @default.
• W2410344554 cites W1985953874 @default.
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• W2410344554 cites W1994033703 @default.
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