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- W2410347669 abstract "Antibody raised against the purified human erythrocyte glucose transporter specifically precipitated four pro- teins from normal and Rous sarcoma virus-transformed chicken embryo cells: a major protein of Mr 41,000 and minor proteins of Mr 68,000, 73,000, and 82,000. The Mr 41,000 and 82,000 proteins were found only in a membrane fraction, not in the soluble frac- tion, and displayed a heterogeneous mobility on NaDodSO4/ polyacrylamide gel electrophoresis, suggesting glycosylation. The Mr 41,000 and 82,000 proteins were increased in amount after malignant transformation in direct proportion to the increase in hexose transport rate, and the increase was dependent on the expression of the src gene product, as revealed with a tempera- ture-conditional src mutant. We suggest that the Mr 41,000 and 82,000 proteins are the glucose transporter of chicken embryo fi- broblasts, or a component of the glucose transporter. These ex- periments provide direct evidence that malignant transformation increases the rate of glucose transport by increasing the number of transporters in the membrane. Malignant transformation of chicken embryo cells by Rous sar- coma virus (RSV) causes a striking increase in the rate at which these cells transport glucose across the cell membrane (1-4)." @default.
- W2410347669 created "2016-06-24" @default.
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- W2410347669 date "2016-01-01" @default.
- W2410347669 modified "2023-09-27" @default.
- W2410347669 title "Proteins antigenically related to th, transporter in normal and Rous sa) chicken embryo fibroblasts (membrane alterations/malignant transformation)" @default.
- W2410347669 hasPublicationYear "2016" @default.
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