Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410366154> ?p ?o ?g. }
- W2410366154 endingPage "71" @default.
- W2410366154 startingPage "5" @default.
- W2410366154 abstract "To begin identifying genes controlling individual susceptibility to particulate matter, responses of inbred mouse strains exposed to nickel sulfate (NiSO4*) were compared with those of mice exposed to ozone (O3) or polytetrafluoroethylene (PTFE). The A strain was sensitive to NiSO4-induced lung injury (quantified by survival time), the C3H/He (C3) strain and several other strains were intermediate in their responses, and the C57BL/6 (B6) strain was resistant. The strains showed a pattern of response similar to the patterns of response to O3 and PTFE. The phenotype of A x B6 offspring (B6AF1) resembled that of the resistant B6 parental strain, with strains exhibiting sensitivity in the order A > C3 > B6 = B6AF1. Pathology was comparable for the A and B6 mice, and exposure to NiSO4 at 15 microg/m3 produced 20% mortality in A mice. Strain sensitivity for the presence of protein or neutrophils in lavage fluid differed from strain sensitivity for survival time, suggesting that they are not causally linked but are controlled by an independent gene or genes. In the B6 strain, exposure to nickel oxide (NiO) by instillation (40 to 1000 nm) or inhalation (50 nm) produced no changes, whereas inhalation of NiSO4 (60 or 250 nm) increased lavage proteins and neutrophils. Complementary DNA (cDNA) microarray analysis with 8,734 sequence-verified clones revealed a temporal pattern of increased oxidative stress, extracellular matrix repair, cell proliferation, and hypoxia, followed by a decrease in surfactant-associated proteins (SPs). Certain expressed sequence tags (ESTs), clustered with known genes, suggest possible coregulation and novel roles in pulmonary injury. Finally, locus number estimation (Wright equation) and a genomewide analysis suggested 5 genes could explain the survival time and identified significant linkage for a quantitative trait locus (QTL) on chromosome 6, Aliq4 (acute lung injury QTL4). Haplotype analysis identified an allelic combination of 5 QTLs that could explain the difference in sensitivity to acute lung injury between parental strains. Positional candidate genes for Aliq4 include aquaporin-1 (Aqp1), SP-B, and transforming growth factor-alpha (TGF-alpha). Transgenic mice expressing TGF-alpha were rescued from NiSO4 injury (that is, they had diminished SP-B loss and increased survival time). These findings suggest that NiSO4-induced acute lung injury is a complex trait controlled by at least 5 genes (all possibly involved in cell proliferation and surfactant function). Future assessment of these susceptibility genes (including evaluations of human synteny and function) could provide valuable insights into individual susceptibility to the adverse effects of particulate matter." @default.
- W2410366154 created "2016-06-24" @default.
- W2410366154 creator A5003302943 @default.
- W2410366154 creator A5009151293 @default.
- W2410366154 creator A5013464628 @default.
- W2410366154 creator A5017765194 @default.
- W2410366154 creator A5035244644 @default.
- W2410366154 creator A5040533368 @default.
- W2410366154 creator A5046357115 @default.
- W2410366154 creator A5050016222 @default.
- W2410366154 creator A5056804689 @default.
- W2410366154 creator A5060875680 @default.
- W2410366154 creator A5061697196 @default.
- W2410366154 creator A5071557383 @default.
- W2410366154 creator A5076094949 @default.
- W2410366154 creator A5085481799 @default.
- W2410366154 creator A5090940538 @default.
- W2410366154 date "2001-12-01" @default.
- W2410366154 modified "2023-10-17" @default.
- W2410366154 title "Pathogenomic mechanisms for particulate matter induction of acute lung injury and inflammation in mice." @default.
- W2410366154 cites W107992251 @default.
- W2410366154 cites W1553386668 @default.
- W2410366154 cites W1570564798 @default.
- W2410366154 cites W1886721973 @default.
- W2410366154 cites W194988083 @default.
- W2410366154 cites W1970465806 @default.
- W2410366154 cites W1988205788 @default.
- W2410366154 cites W1990054797 @default.
- W2410366154 cites W1991049796 @default.
- W2410366154 cites W1994440230 @default.
- W2410366154 cites W2010401309 @default.
- W2410366154 cites W2018066428 @default.
- W2410366154 cites W2026811587 @default.
- W2410366154 cites W2033933117 @default.
- W2410366154 cites W2037813697 @default.
- W2410366154 cites W2051056083 @default.
- W2410366154 cites W2058713921 @default.
- W2410366154 cites W2059536479 @default.
- W2410366154 cites W2068229778 @default.
- W2410366154 cites W2073872478 @default.
- W2410366154 cites W2081745487 @default.
- W2410366154 cites W2083345304 @default.
- W2410366154 cites W2149301933 @default.
- W2410366154 cites W2169046198 @default.
- W2410366154 cites W2237250304 @default.
- W2410366154 cites W2267742187 @default.
- W2410366154 cites W2340502484 @default.
- W2410366154 cites W2406403279 @default.
- W2410366154 cites W2463496633 @default.
- W2410366154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11954676" @default.
- W2410366154 hasPublicationYear "2001" @default.
- W2410366154 type Work @default.
- W2410366154 sameAs 2410366154 @default.
- W2410366154 citedByCount "7" @default.
- W2410366154 countsByYear W24103661542012 @default.
- W2410366154 countsByYear W24103661542019 @default.
- W2410366154 crossrefType "journal-article" @default.
- W2410366154 hasAuthorship W2410366154A5003302943 @default.
- W2410366154 hasAuthorship W2410366154A5009151293 @default.
- W2410366154 hasAuthorship W2410366154A5013464628 @default.
- W2410366154 hasAuthorship W2410366154A5017765194 @default.
- W2410366154 hasAuthorship W2410366154A5035244644 @default.
- W2410366154 hasAuthorship W2410366154A5040533368 @default.
- W2410366154 hasAuthorship W2410366154A5046357115 @default.
- W2410366154 hasAuthorship W2410366154A5050016222 @default.
- W2410366154 hasAuthorship W2410366154A5056804689 @default.
- W2410366154 hasAuthorship W2410366154A5060875680 @default.
- W2410366154 hasAuthorship W2410366154A5061697196 @default.
- W2410366154 hasAuthorship W2410366154A5071557383 @default.
- W2410366154 hasAuthorship W2410366154A5076094949 @default.
- W2410366154 hasAuthorship W2410366154A5085481799 @default.
- W2410366154 hasAuthorship W2410366154A5090940538 @default.
- W2410366154 hasConcept C104317684 @default.
- W2410366154 hasConcept C105702510 @default.
- W2410366154 hasConcept C143425029 @default.
- W2410366154 hasConcept C150194340 @default.
- W2410366154 hasConcept C153911025 @default.
- W2410366154 hasConcept C185592680 @default.
- W2410366154 hasConcept C186836561 @default.
- W2410366154 hasConcept C187882448 @default.
- W2410366154 hasConcept C203014093 @default.
- W2410366154 hasConcept C2776151105 @default.
- W2410366154 hasConcept C2776914184 @default.
- W2410366154 hasConcept C2776954882 @default.
- W2410366154 hasConcept C2778022156 @default.
- W2410366154 hasConcept C2779777708 @default.
- W2410366154 hasConcept C54355233 @default.
- W2410366154 hasConcept C552990157 @default.
- W2410366154 hasConcept C55493867 @default.
- W2410366154 hasConcept C86803240 @default.
- W2410366154 hasConceptScore W2410366154C104317684 @default.
- W2410366154 hasConceptScore W2410366154C105702510 @default.
- W2410366154 hasConceptScore W2410366154C143425029 @default.
- W2410366154 hasConceptScore W2410366154C150194340 @default.
- W2410366154 hasConceptScore W2410366154C153911025 @default.
- W2410366154 hasConceptScore W2410366154C185592680 @default.
- W2410366154 hasConceptScore W2410366154C186836561 @default.
- W2410366154 hasConceptScore W2410366154C187882448 @default.