Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410373344> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2410373344 endingPage "F116" @default.
- W2410373344 startingPage "F108" @default.
- W2410373344 abstract "We examined the effect of platelet-activating factor (PAF) on renal vascular reactivity in the pentobarbital sodium-anesthetized male Wistar rat. Intrarenal infusion of C16-PAF at hypotensive (2.5 ng.min-1.kg-1) or nonhypotensive (0.5 ng.min-1.kg-1) doses caused renal vasodilation and dose dependently antagonized the renal vasoconstrictor responses of intrarenal boluses of angiotensin II (ANG II) greater than norepinephrine (NE) greater than vasopressin (AVP). PAF infusion at the high dose did not alter non-receptor-mediated renal vasoconstriction induced by intrarenal KCl injection. The inhibitory effect of PAF on agonist-induced renal vasoconstriction was accentuated by eicosanoid synthesis inhibition (indomethacin or dexamethasone), unaffected by dopamine-receptor blockade (haloperidol) but was totally abolished by PAF receptor antagonism (L-659,989). In contrast, intrarenal infusion of a calcium channel antagonist (nimodipine) or an intracellular calcium channel antagonist (TMB-8) equally inhibited the renal vasoconstrictor responses of ANG II, NE, and AVP. Thus PAF can cause renal vasodilation in the rat kidney and dose-dependently antagonizes the renal vasoconstrictor responses of ANG II greater than NE greater than AVP. The inhibitory effect of PAF on renal vasoconstrictor responses is mediated by PAF receptors and does not appear to be due to a nonspecific membrane effect, reduction in calcium mobilization, or the release of vasodilatory eicosanoids or dopamine." @default.
- W2410373344 created "2016-06-24" @default.
- W2410373344 creator A5025147697 @default.
- W2410373344 creator A5075187095 @default.
- W2410373344 creator A5080584791 @default.
- W2410373344 date "1991-07-01" @default.
- W2410373344 modified "2023-09-27" @default.
- W2410373344 title "Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney" @default.
- W2410373344 doi "https://doi.org/10.1152/ajprenal.1991.261.1.f108" @default.
- W2410373344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1907104" @default.
- W2410373344 hasPublicationYear "1991" @default.
- W2410373344 type Work @default.
- W2410373344 sameAs 2410373344 @default.
- W2410373344 citedByCount "7" @default.
- W2410373344 countsByYear W24103733442015 @default.
- W2410373344 countsByYear W24103733442016 @default.
- W2410373344 crossrefType "journal-article" @default.
- W2410373344 hasAuthorship W2410373344A5025147697 @default.
- W2410373344 hasAuthorship W2410373344A5075187095 @default.
- W2410373344 hasAuthorship W2410373344A5080584791 @default.
- W2410373344 hasConcept C126322002 @default.
- W2410373344 hasConcept C134018914 @default.
- W2410373344 hasConcept C142225936 @default.
- W2410373344 hasConcept C170493617 @default.
- W2410373344 hasConcept C185592680 @default.
- W2410373344 hasConcept C2776370428 @default.
- W2410373344 hasConcept C2779020240 @default.
- W2410373344 hasConcept C2779961880 @default.
- W2410373344 hasConcept C2780091579 @default.
- W2410373344 hasConcept C2781073237 @default.
- W2410373344 hasConcept C2908929049 @default.
- W2410373344 hasConcept C71924100 @default.
- W2410373344 hasConcept C98274493 @default.
- W2410373344 hasConceptScore W2410373344C126322002 @default.
- W2410373344 hasConceptScore W2410373344C134018914 @default.
- W2410373344 hasConceptScore W2410373344C142225936 @default.
- W2410373344 hasConceptScore W2410373344C170493617 @default.
- W2410373344 hasConceptScore W2410373344C185592680 @default.
- W2410373344 hasConceptScore W2410373344C2776370428 @default.
- W2410373344 hasConceptScore W2410373344C2779020240 @default.
- W2410373344 hasConceptScore W2410373344C2779961880 @default.
- W2410373344 hasConceptScore W2410373344C2780091579 @default.
- W2410373344 hasConceptScore W2410373344C2781073237 @default.
- W2410373344 hasConceptScore W2410373344C2908929049 @default.
- W2410373344 hasConceptScore W2410373344C71924100 @default.
- W2410373344 hasConceptScore W2410373344C98274493 @default.
- W2410373344 hasIssue "1" @default.
- W2410373344 hasLocation W24103733441 @default.
- W2410373344 hasLocation W24103733442 @default.
- W2410373344 hasOpenAccess W2410373344 @default.
- W2410373344 hasPrimaryLocation W24103733441 @default.
- W2410373344 hasRelatedWork W1988635821 @default.
- W2410373344 hasRelatedWork W2035770909 @default.
- W2410373344 hasRelatedWork W2047925791 @default.
- W2410373344 hasRelatedWork W2058871240 @default.
- W2410373344 hasRelatedWork W2096862433 @default.
- W2410373344 hasRelatedWork W2098573214 @default.
- W2410373344 hasRelatedWork W2270603767 @default.
- W2410373344 hasRelatedWork W2404152533 @default.
- W2410373344 hasRelatedWork W2410373344 @default.
- W2410373344 hasRelatedWork W2472073749 @default.
- W2410373344 hasVolume "261" @default.
- W2410373344 isParatext "false" @default.
- W2410373344 isRetracted "false" @default.
- W2410373344 magId "2410373344" @default.
- W2410373344 workType "article" @default.