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- W2410399319 abstract "A 12-week trial with insulin and rhIGF-I compared to insulin and placebo was conducted in patients with type 1 diabetes mellitus aged 11-66 years. We present the efficacy and safety data pertinent to the younger subset of participants (11-21 years).The patients were randomized to receive s.c. insulin and either placebo or rhIGF-I at one of the following doses (microg/kg): 40 a.m./40 p.m., 80 a.m./40 p.m. or 80 a.m./60 p.m.).The average decrease of HbA1c from baseline was higher (-1.3 +/- 0.2%) in the rhIGF-I treated group compared to the placebo group (-0.6 +/- 0.3%; p <0.05). This was associated with a significant decrease in daily insulin dose (U) of both Regular (rhIGF-I: -7 +/- 1; placebo: -1 +/- 1; p <0.01) and NPH (rhIGF-I: -4 +/- 2; placebo: +5 +/- 3; p <0.05). The incidence of hypoglycemia and weight gain were not increased. Edema, jaw pain and tachycardia were associated with rhIGF-I treatment, particularly at doses higher than 40 microg/kg b.i.d. Dose-related early worsening of retinopathy was observed in 11/55 patients in the rhIGF-I group, with resolution in the majority of them in the follow-up photographs.These findings suggest a possible role for rhIGF-I co-therapy in adolescents and young adults with type 1 diabetes mellitus." @default.
- W2410399319 created "2016-06-24" @default.
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- W2410399319 date "2001-01-01" @default.
- W2410399319 modified "2023-09-23" @default.
- W2410399319 title "Improvement of HbA1c Without Increased Hypoglycemia in Adolescents and Young Adults with Type 1 Diabetes Mellitus Treated with Recombinant Human Insulin-like Growth Factor-I and Insulin" @default.
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- W2410399319 doi "https://doi.org/10.1515/jpem.2001.14.3.267" @default.
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