Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410492757> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2410492757 endingPage "104" @default.
- W2410492757 startingPage "91" @default.
- W2410492757 abstract "In rat brain membrane preparations, the parenterally and orally active peptide, [D-Ala2, MePhe4, Met(O)5-ol]-enkephalin, binds to morphine receptor sites ([3H]naloxone or [3H]dihydromorphine binding sites) with an affinity higher than that for enkephalin receptor sites ([125I] [D-Ala2, D-Leu5]-enkephalin binding sites). [125I] [D-Ala2, MePhe4, Met(O)5-ol]-enkephalin binds to morphine receptor sites stereospecifically, in a saturable manner and with characteristics similar to that of [3H]dihydromorphine; this ligand can be used as an 125I-labeled probe to measure specific binding to morphine receptor sites. Na+ decreases and Mn2+ increases the binding capacity with a concomitant reduction of affinity for [125I] [D-Ala2, MePhe4, Met(O)5-ol]-enkephalin. This peptide does not bind to neuroblastoma cells with high affinity. The brain regional distribution of binding of [125I] [D-Ala2, MePhe4, Met(O)5-ol]-enkephalin or [3H]naloxone and [125I] [D-Ala2, D-Leu5]-enkephalin are different. The differential potency of binding of opiate agonists, antagonists, mixed agonist-antagonists, enkephalins and enkephalin analogues is studied by competition of binding of [3H]naloxone or [125I] [D-Ala2, MePhe4, Met(O)5-ol]-enkephalin (morphine receptor) and of [125I] [D-Ala2, D-Leu5]-enkephalin sites (enkephalin receptor). All of these results support the contention that there are multiple opiate receptors with differing characteristics." @default.
- W2410492757 created "2016-06-24" @default.
- W2410492757 creator A5057927191 @default.
- W2410492757 creator A5067055601 @default.
- W2410492757 creator A5068145395 @default.
- W2410492757 creator A5083773123 @default.
- W2410492757 date "1979-07-01" @default.
- W2410492757 modified "2023-10-10" @default.
- W2410492757 title "Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides." @default.
- W2410492757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/225656" @default.
- W2410492757 hasPublicationYear "1979" @default.
- W2410492757 type Work @default.
- W2410492757 sameAs 2410492757 @default.
- W2410492757 citedByCount "131" @default.
- W2410492757 countsByYear W24104927572013 @default.
- W2410492757 countsByYear W24104927572022 @default.
- W2410492757 crossrefType "journal-article" @default.
- W2410492757 hasAuthorship W2410492757A5057927191 @default.
- W2410492757 hasAuthorship W2410492757A5067055601 @default.
- W2410492757 hasAuthorship W2410492757A5068145395 @default.
- W2410492757 hasAuthorship W2410492757A5083773123 @default.
- W2410492757 hasConcept C170493617 @default.
- W2410492757 hasConcept C185592680 @default.
- W2410492757 hasConcept C2776401185 @default.
- W2410492757 hasConcept C2777389121 @default.
- W2410492757 hasConcept C2777803847 @default.
- W2410492757 hasConcept C2778140631 @default.
- W2410492757 hasConcept C2778750930 @default.
- W2410492757 hasConcept C2778938600 @default.
- W2410492757 hasConcept C2781063702 @default.
- W2410492757 hasConcept C55493867 @default.
- W2410492757 hasConcept C86803240 @default.
- W2410492757 hasConcept C88016717 @default.
- W2410492757 hasConcept C98274493 @default.
- W2410492757 hasConceptScore W2410492757C170493617 @default.
- W2410492757 hasConceptScore W2410492757C185592680 @default.
- W2410492757 hasConceptScore W2410492757C2776401185 @default.
- W2410492757 hasConceptScore W2410492757C2777389121 @default.
- W2410492757 hasConceptScore W2410492757C2777803847 @default.
- W2410492757 hasConceptScore W2410492757C2778140631 @default.
- W2410492757 hasConceptScore W2410492757C2778750930 @default.
- W2410492757 hasConceptScore W2410492757C2778938600 @default.
- W2410492757 hasConceptScore W2410492757C2781063702 @default.
- W2410492757 hasConceptScore W2410492757C55493867 @default.
- W2410492757 hasConceptScore W2410492757C86803240 @default.
- W2410492757 hasConceptScore W2410492757C88016717 @default.
- W2410492757 hasConceptScore W2410492757C98274493 @default.
- W2410492757 hasIssue "1" @default.
- W2410492757 hasLocation W24104927571 @default.
- W2410492757 hasOpenAccess W2410492757 @default.
- W2410492757 hasPrimaryLocation W24104927571 @default.
- W2410492757 hasRelatedWork W160655327 @default.
- W2410492757 hasRelatedWork W2007180342 @default.
- W2410492757 hasRelatedWork W2040753312 @default.
- W2410492757 hasRelatedWork W207497960 @default.
- W2410492757 hasRelatedWork W2081927982 @default.
- W2410492757 hasRelatedWork W2139348786 @default.
- W2410492757 hasRelatedWork W2235671932 @default.
- W2410492757 hasRelatedWork W2399769055 @default.
- W2410492757 hasRelatedWork W2414217834 @default.
- W2410492757 hasRelatedWork W2505873267 @default.
- W2410492757 hasVolume "16" @default.
- W2410492757 isParatext "false" @default.
- W2410492757 isRetracted "false" @default.
- W2410492757 magId "2410492757" @default.
- W2410492757 workType "article" @default.