Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410495950> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2410495950 endingPage "201" @default.
- W2410495950 startingPage "180" @default.
- W2410495950 abstract "Urapidil is a novel antihypertensive agent, chemically related to uracil. Its cardiovascular profile was evaluated in a variety of pharmacological models. Urapidil caused a significant decrease of blood pressure in intact rats, both hypertensive (SHR) and normotensive (WKY), as well as in alpha-glucochloralose-anaesthetized cats. Reflex tachycardia was not observed. An analysis in pithed rats showed that urapidil is an alpha-adrenoceptor blocking drug with an obvious selectivity for postsynaptic alpha 1- over alpha 2-adrenoceptors. The alpha 1-adrenoceptor blocking potency proved quantitatively less than that of prazosin. Experiments on isolated aorta preparations and radioligand binding studies confirmed the selectivity of urapidil for alpha 1- over alpha 2-adrenoceptors. The involvement of urapidil with presynaptic alpha 2-adrenoceptors proved negligible. Urapidil proved to possess modest but significant beta 1-adrenoceptor blocking activity, accompanied by a certain degree of intrinsic sympathomimetic activity (TSA) at the level of the cardiac beta 1-adrenoceptors. No significant interaction with vascular beta 2-adrenoceptors was observed. High doses of urapidil caused pressor effects of a probably unspecific nature; neither alpha-adrenoceptors nor 5HT-receptors were involved. When injected into the vertebral artery of the cat, urapidil caused a significant central hypotensive effect which was different from that of clonidine and related drugs, since it could not be blocked by yohimbine (alpha 2-receptor antagonist). Similarly, the modest sedation produced by urapidil in mice remained uninfluenced by yohimbine. The urapidil molecule does not contain any stereoisomers. Accordingly, one and the same molecule possesses the following pharmacodynamic properties: postsynaptic alpha 1-adrenoceptor blockade; weak postsynaptic alpha 2-adrenoceptor blockade; modest but selective beta 1-adrenoceptor blockade with ISA; central hypotensive activity not mediated by central alpha 2-adrenoceptors." @default.
- W2410495950 created "2016-06-24" @default.
- W2410495950 creator A5016606239 @default.
- W2410495950 creator A5031897869 @default.
- W2410495950 creator A5074447099 @default.
- W2410495950 date "1985-08-01" @default.
- W2410495950 modified "2023-09-23" @default.
- W2410495950 title "Cardiovascular effects and interaction with adrenoceptors of urapidil." @default.
- W2410495950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4051641" @default.
- W2410495950 hasPublicationYear "1985" @default.
- W2410495950 type Work @default.
- W2410495950 sameAs 2410495950 @default.
- W2410495950 citedByCount "29" @default.
- W2410495950 crossrefType "journal-article" @default.
- W2410495950 hasAuthorship W2410495950A5016606239 @default.
- W2410495950 hasAuthorship W2410495950A5031897869 @default.
- W2410495950 hasAuthorship W2410495950A5074447099 @default.
- W2410495950 hasConcept C126322002 @default.
- W2410495950 hasConcept C134018914 @default.
- W2410495950 hasConcept C159110408 @default.
- W2410495950 hasConcept C170493617 @default.
- W2410495950 hasConcept C185592680 @default.
- W2410495950 hasConcept C197341189 @default.
- W2410495950 hasConcept C2775944032 @default.
- W2410495950 hasConcept C2776885963 @default.
- W2410495950 hasConcept C2777676773 @default.
- W2410495950 hasConcept C2777953023 @default.
- W2410495950 hasConcept C2778040405 @default.
- W2410495950 hasConcept C2780648677 @default.
- W2410495950 hasConcept C49453240 @default.
- W2410495950 hasConcept C64943373 @default.
- W2410495950 hasConcept C71924100 @default.
- W2410495950 hasConcept C84393581 @default.
- W2410495950 hasConcept C98274493 @default.
- W2410495950 hasConceptScore W2410495950C126322002 @default.
- W2410495950 hasConceptScore W2410495950C134018914 @default.
- W2410495950 hasConceptScore W2410495950C159110408 @default.
- W2410495950 hasConceptScore W2410495950C170493617 @default.
- W2410495950 hasConceptScore W2410495950C185592680 @default.
- W2410495950 hasConceptScore W2410495950C197341189 @default.
- W2410495950 hasConceptScore W2410495950C2775944032 @default.
- W2410495950 hasConceptScore W2410495950C2776885963 @default.
- W2410495950 hasConceptScore W2410495950C2777676773 @default.
- W2410495950 hasConceptScore W2410495950C2777953023 @default.
- W2410495950 hasConceptScore W2410495950C2778040405 @default.
- W2410495950 hasConceptScore W2410495950C2780648677 @default.
- W2410495950 hasConceptScore W2410495950C49453240 @default.
- W2410495950 hasConceptScore W2410495950C64943373 @default.
- W2410495950 hasConceptScore W2410495950C71924100 @default.
- W2410495950 hasConceptScore W2410495950C84393581 @default.
- W2410495950 hasConceptScore W2410495950C98274493 @default.
- W2410495950 hasIssue "2" @default.
- W2410495950 hasLocation W24104959501 @default.
- W2410495950 hasOpenAccess W2410495950 @default.
- W2410495950 hasPrimaryLocation W24104959501 @default.
- W2410495950 hasRelatedWork W1975482376 @default.
- W2410495950 hasRelatedWork W2013457480 @default.
- W2410495950 hasRelatedWork W2018648730 @default.
- W2410495950 hasRelatedWork W2026902857 @default.
- W2410495950 hasRelatedWork W2104839745 @default.
- W2410495950 hasRelatedWork W2165958118 @default.
- W2410495950 hasRelatedWork W2349986033 @default.
- W2410495950 hasRelatedWork W2463848598 @default.
- W2410495950 hasRelatedWork W3027395595 @default.
- W2410495950 hasRelatedWork W2268553388 @default.
- W2410495950 hasVolume "276" @default.
- W2410495950 isParatext "false" @default.
- W2410495950 isRetracted "false" @default.
- W2410495950 magId "2410495950" @default.
- W2410495950 workType "article" @default.