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• W2410508711 abstract "Abstract In order to increase the therapeutic effect of doxorubicin (DOX) on bone metastases, a multifunctional micelle was developed by combining pH-sensitive characteristics with bone active targeting capacity. The DOX loaded micelle was self-assembled by using doxorubicin-poly (ethylene glycol)-alendronate (DOX-hyd-PEG-ALN) as an amphiphilic material. The size and drug loading of DOX loaded DOX-hyd-PEG-ALN micelle was 114 nm and 24.3%. In pH 5.0 phosphate buffer solution (PBS), the micelle released DOX significantly faster than in pH 7.4 PBS. In addition, with the increase of incubation time, more red DOX fluorescence was observed in tumor cells and trafficked from cytoplasm to nucleus. The IC 50 of DOX loaded DOX-hyd-PEG-ALN micelle on A549 cells was obviously lower than that of free DOX in 48 h. Furthermore, the in vivo image experimental results indicated that a larger amount of DOX was accumulated in the bone metastatic tumor tissue after DOX loaded DOX-hyd-PEG-ALN micelle was intravenously administered, which was confirmed by histological analysis. Finally, DOX loaded DOX-hyd-PEG-ALN micelle effectively delayed the tumor growth, decreased the bone loss and reduced the cardiac toxicity in tumor-bearing nude mice as compared with free DOX. In conclusion, DOX loaded DOX-hyd-PEG-ALN micelle had potential in treating bone metastatic tumor." @default.
• W2410508711 created "2016-06-24" @default.
• W2410508711 creator A5005228021 @default.
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• W2410508711 date "2015-09-30" @default.
• W2410508711 modified "2023-10-18" @default.
• W2410508711 title "Doxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer" @default.
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• W2410508711 doi "https://doi.org/10.1038/srep14614" @default.
• W2410508711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4588583" @default.
• W2410508711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26419507" @default.
• W2410508711 hasPublicationYear "2015" @default.
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