Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410528022> ?p ?o ?g. }
- W2410528022 endingPage "670" @default.
- W2410528022 startingPage "661" @default.
- W2410528022 abstract "Cardiac glycosides (CGs) or cardiotonic steroids, which constitute a group of naturally occurring compounds with a steroid-like structure, can act on Na+/K+-ATPase as a receptor and activate intracellular signaling messengers leading to a variety of cellular responses. Epidemiological studies have revealed that CGs, used for the treatment of cardiac disorders, may also be beneficial as anti-cancer agents. CGs, acting in combination with other chemotherapeutic agents, may significantly alter their efficiency in relation to cancer cell elimination, causing both sensitization and an increase in cancer cell death, and in some cases resistance to chemotherapy. Here we show the ability of CGs to modulate apoptotic response to conventionally used anti-cancer drugs. In combination with etoposide, CGs digoxin may enhance cytotoxic potential, thereby allowing the chemotherapeutic dose to be decreased and minimizing toxicity and adverse reactions. Mechanisms behind this event are discussed." @default.
- W2410528022 created "2016-06-24" @default.
- W2410528022 creator A5018062236 @default.
- W2410528022 creator A5030506274 @default.
- W2410528022 creator A5065353510 @default.
- W2410528022 creator A5077812273 @default.
- W2410528022 creator A5080920861 @default.
- W2410528022 date "2016-02-06" @default.
- W2410528022 modified "2023-09-26" @default.
- W2410528022 title "Contrasting effects of cardiac glycosides on cisplatin- and etoposide-induced cell death" @default.
- W2410528022 cites W1508704511 @default.
- W2410528022 cites W1777419882 @default.
- W2410528022 cites W1966279057 @default.
- W2410528022 cites W1966704219 @default.
- W2410528022 cites W1976686960 @default.
- W2410528022 cites W1979328312 @default.
- W2410528022 cites W1981337355 @default.
- W2410528022 cites W1987854760 @default.
- W2410528022 cites W2004493226 @default.
- W2410528022 cites W2012823597 @default.
- W2410528022 cites W2014438209 @default.
- W2410528022 cites W2016741939 @default.
- W2410528022 cites W2017291180 @default.
- W2410528022 cites W2017555666 @default.
- W2410528022 cites W2032458313 @default.
- W2410528022 cites W2036050079 @default.
- W2410528022 cites W2043606739 @default.
- W2410528022 cites W2045108560 @default.
- W2410528022 cites W2047312053 @default.
- W2410528022 cites W2048670006 @default.
- W2410528022 cites W2053829698 @default.
- W2410528022 cites W2054463453 @default.
- W2410528022 cites W2057609544 @default.
- W2410528022 cites W2069034973 @default.
- W2410528022 cites W2069529251 @default.
- W2410528022 cites W2072142448 @default.
- W2410528022 cites W2081787890 @default.
- W2410528022 cites W2084250387 @default.
- W2410528022 cites W2096499561 @default.
- W2410528022 cites W2096806100 @default.
- W2410528022 cites W2112302797 @default.
- W2410528022 cites W2130400575 @default.
- W2410528022 cites W2135664375 @default.
- W2410528022 cites W2136985880 @default.
- W2410528022 cites W2143617499 @default.
- W2410528022 cites W2144470409 @default.
- W2410528022 cites W2167883287 @default.
- W2410528022 cites W4211179856 @default.
- W2410528022 doi "https://doi.org/10.1515/hsz-2016-0101" @default.
- W2410528022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26854291" @default.
- W2410528022 hasPublicationYear "2016" @default.
- W2410528022 type Work @default.
- W2410528022 sameAs 2410528022 @default.
- W2410528022 citedByCount "3" @default.
- W2410528022 countsByYear W24105280222017 @default.
- W2410528022 crossrefType "journal-article" @default.
- W2410528022 hasAuthorship W2410528022A5018062236 @default.
- W2410528022 hasAuthorship W2410528022A5030506274 @default.
- W2410528022 hasAuthorship W2410528022A5065353510 @default.
- W2410528022 hasAuthorship W2410528022A5077812273 @default.
- W2410528022 hasAuthorship W2410528022A5080920861 @default.
- W2410528022 hasConcept C121608353 @default.
- W2410528022 hasConcept C126322002 @default.
- W2410528022 hasConcept C178790620 @default.
- W2410528022 hasConcept C185592680 @default.
- W2410528022 hasConcept C194671627 @default.
- W2410528022 hasConcept C203014093 @default.
- W2410528022 hasConcept C2776217527 @default.
- W2410528022 hasConcept C2776694085 @default.
- W2410528022 hasConcept C2777707475 @default.
- W2410528022 hasConcept C2778119113 @default.
- W2410528022 hasConcept C2778198053 @default.
- W2410528022 hasConcept C2778233292 @default.
- W2410528022 hasConcept C2778239845 @default.
- W2410528022 hasConcept C2779133857 @default.
- W2410528022 hasConcept C2780257055 @default.
- W2410528022 hasConcept C2780557390 @default.
- W2410528022 hasConcept C29730261 @default.
- W2410528022 hasConcept C537181965 @default.
- W2410528022 hasConcept C55493867 @default.
- W2410528022 hasConcept C71240020 @default.
- W2410528022 hasConcept C71924100 @default.
- W2410528022 hasConcept C79879829 @default.
- W2410528022 hasConcept C96232424 @default.
- W2410528022 hasConcept C98274493 @default.
- W2410528022 hasConceptScore W2410528022C121608353 @default.
- W2410528022 hasConceptScore W2410528022C126322002 @default.
- W2410528022 hasConceptScore W2410528022C178790620 @default.
- W2410528022 hasConceptScore W2410528022C185592680 @default.
- W2410528022 hasConceptScore W2410528022C194671627 @default.
- W2410528022 hasConceptScore W2410528022C203014093 @default.
- W2410528022 hasConceptScore W2410528022C2776217527 @default.
- W2410528022 hasConceptScore W2410528022C2776694085 @default.
- W2410528022 hasConceptScore W2410528022C2777707475 @default.
- W2410528022 hasConceptScore W2410528022C2778119113 @default.
- W2410528022 hasConceptScore W2410528022C2778198053 @default.
- W2410528022 hasConceptScore W2410528022C2778233292 @default.
- W2410528022 hasConceptScore W2410528022C2778239845 @default.