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- W2410564659 abstract "Background Acute presentation of severe autoimmune thrombocytopenia (AT) and hemolytic anemia (AHA) in systemic lupus erythematosus (SLE) is associated with high mortality. Splenectomy is the second line of treatment Objectives Investigate the efficacy and safety of splenectomy in SLE patients compared with patients without SLE presenting acute, severe, refractory, life threatening AT and AHA. Methods From January 2004 to April 2014, 34 patients underwent splenectomy. The patients were divided into two groups. Group 1, 18 patients with AT-SLE/APSA. Group 2: 16 patients without SLE: AT/AHA. Demographic and clinical data were analyze. Refractory hematological manifestations were defined according to Mayo Clinic Criteria as: 1. If patients did not maintain platelets ≥50,000 per ml for 2 weeks on medical therapy; 2. Medically dependent. 3. Medically intolerant. Patients with hemolytic anemia were submitted to surgery when they developed 2 hemolytic crisis (fever, jaudice, pallor, abdominal pain, and haemoglobin ≤6 gr/dL) despite to conventional treatment over a period of 6 months. After splenectomy, the response were considered for thrombocytopenia as follows: 1. Complete response: ≥150,000 platelets per ml, 2. Partial response: 50,000 to 149,000 per ml or 3. No response: Results The mean age of 34 patients (28 female) were 34.6 years old (range 18-62 y.o.). The duration of disease:Group 1 vs Group 2: 58.3±50.6 vs 27.13±27.9 months (p Conclusions This study suggest:Despite the long duration of disease, patients with SLE/APS have a similar response to splenectomy compared with AT/AHA. Patients with SLE/APS had a significant increase of relapses. The splenectomy is safety and effective in severe and refractory hematologic manifestations. Disclosure of Interest None declared" @default.
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- W2410564659 date "2015-06-01" @default.
- W2410564659 modified "2023-09-27" @default.
- W2410564659 title "AB0523 Splenectomy in Systemic Lupus Erythematosus Versus Autoimmune Hematological Diseases: To Late or to Early?" @default.
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- W2410564659 doi "https://doi.org/10.1136/annrheumdis-2015-eular.6393" @default.
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