FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410578842> ?p ?o ?g. }

• W2410578842 endingPage "99" @default.
• W2410578842 startingPage "94" @default.
• W2410578842 abstract "Up to 84% of prematurely born infants suffer hypoxic, anoxic, and ischemic insults. Those infants with subsequent behavioral, motor or cognitive dysfunction represent 8-11% of all live births. Yet, no interventions employed during pregnancy attenuate risk of morbidity in those at-risk infants. Dietary supplementation with omega-3 polyunsaturated fatty acids (ω-3 PUFAs) has been shown to reduce stroke-induced neuropathology in rat models emulating this adverse clinical event. To extend those studies we sought to determine whether maternal dietary supplementation with ω-3 PUFAs would confer neuroprotection against hypoxia-induced neurochemical dysfunction in newborn rat pups exposed to repetitive hypoxic insults.We provided pregnant rats with either a ω-3 PUFA enriched diet or else a standard rat chow diet. At postnatal day 7, pups were assigned randomly to either repetitive hypoxic insults or repetitive bursts of room air. On postnatal day 12, pups were sacrificed and brain dopamine levels characterized.Baseline brain dopamine levels did not differ between rat pups born to dams who received ω-3 PUFA enriched versus standard rat chow diets. Rat pups born to dams maintained on normal diets, who were exposed to five days of repetitive hypoxic insults, experienced a 57% reduction in striatal dopamine levels accompanied by significant apoptosis. In contrast, ω-3 PUFA-enriched newborn pups experienced no loss in striatal dopamine levels, and only minimal apoptosis.Our findings suggest that it may be feasible to confer neuroprotection against hypoxia-induced dopamine dysfunction to newborns likely to experience hypoxic insults. This could significantly improve the outcomes of those 8-11% of newborns who would otherwise experience hypoxia-induced behavioral, motor and cognitive dysfunction." @default.
• W2410578842 created "2016-06-24" @default.
• W2410578842 creator A5015104654 @default.
• W2410578842 creator A5021199191 @default.
• W2410578842 creator A5046116573 @default.
• W2410578842 creator A5072820419 @default.
• W2410578842 creator A5085956032 @default.
• W2410578842 date "2016-04-01" @default.
• W2410578842 modified "2023-10-17" @default.
• W2410578842 title "Maternal dietary supplementation with omega-3 polyunsaturated fatty acids confers neuroprotection to the newborn against hypoxia-induced dopamine dysfunction" @default.
• W2410578842 cites W1502328694 @default.
• W2410578842 cites W1574197432 @default.
• W2410578842 cites W1965353262 @default.
• W2410578842 cites W1970336470 @default.
• W2410578842 cites W1974903095 @default.
• W2410578842 cites W1988645552 @default.
• W2410578842 cites W1994520098 @default.
• W2410578842 cites W2000407434 @default.
• W2410578842 cites W2012763600 @default.
• W2410578842 cites W2021085622 @default.
• W2410578842 cites W2021593749 @default.
• W2410578842 cites W2026377968 @default.
• W2410578842 cites W2030843617 @default.
• W2410578842 cites W2045159124 @default.
• W2410578842 cites W2048025784 @default.
• W2410578842 cites W2048457876 @default.
• W2410578842 cites W2053264932 @default.
• W2410578842 cites W2054452487 @default.
• W2410578842 cites W2056225232 @default.
• W2410578842 cites W2057128909 @default.
• W2410578842 cites W2096367894 @default.
• W2410578842 cites W2102246169 @default.
• W2410578842 cites W2105216388 @default.
• W2410578842 cites W2105277370 @default.
• W2410578842 cites W2107189849 @default.
• W2410578842 cites W2111754464 @default.
• W2410578842 cites W2115043296 @default.
• W2410578842 cites W2119011201 @default.
• W2410578842 cites W2119385354 @default.
• W2410578842 cites W2124690429 @default.
• W2410578842 cites W2125365953 @default.
• W2410578842 cites W2127510146 @default.
• W2410578842 cites W2130249957 @default.
• W2410578842 cites W2131070866 @default.
• W2410578842 cites W2131205413 @default.
• W2410578842 cites W2132122521 @default.
• W2410578842 cites W2146768128 @default.
• W2410578842 cites W2158625981 @default.
• W2410578842 cites W2163651203 @default.
• W2410578842 cites W2163790962 @default.
• W2410578842 cites W2167556439 @default.
• W2410578842 cites W2170637026 @default.
• W2410578842 cites W2233089481 @default.
• W2410578842 cites W2267206153 @default.
• W2410578842 cites W2277945433 @default.
• W2410578842 cites W2410030663 @default.
• W2410578842 cites W2412072279 @default.
• W2410578842 cites W2416062764 @default.
• W2410578842 doi "https://doi.org/10.1016/j.slsci.2016.05.007" @default.
• W2410578842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5021959" @default.
• W2410578842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27656273" @default.
• W2410578842 hasPublicationYear "2016" @default.
• W2410578842 type Work @default.
• W2410578842 sameAs 2410578842 @default.
• W2410578842 citedByCount "5" @default.
• W2410578842 countsByYear W24105788422018 @default.
• W2410578842 countsByYear W24105788422019 @default.
• W2410578842 countsByYear W24105788422021 @default.
• W2410578842 crossrefType "journal-article" @default.
• W2410578842 hasAuthorship W2410578842A5015104654 @default.
• W2410578842 hasAuthorship W2410578842A5021199191 @default.
• W2410578842 hasAuthorship W2410578842A5046116573 @default.
• W2410578842 hasAuthorship W2410578842A5072820419 @default.
• W2410578842 hasAuthorship W2410578842A5085956032 @default.
• W2410578842 hasBestOaLocation W24105788421 @default.
• W2410578842 hasConcept C126322002 @default.
• W2410578842 hasConcept C134018914 @default.
• W2410578842 hasConcept C178790620 @default.
• W2410578842 hasConcept C185592680 @default.
• W2410578842 hasConcept C19038510 @default.
• W2410578842 hasConcept C25498285 @default.
• W2410578842 hasConcept C25876315 @default.
• W2410578842 hasConcept C2779134260 @default.
• W2410578842 hasConcept C2780130745 @default.
• W2410578842 hasConcept C42407357 @default.
• W2410578842 hasConcept C513476851 @default.
• W2410578842 hasConcept C540031477 @default.
• W2410578842 hasConcept C543025807 @default.
• W2410578842 hasConcept C55493867 @default.
• W2410578842 hasConcept C71924100 @default.
• W2410578842 hasConcept C7836513 @default.
• W2410578842 hasConcept C86803240 @default.
• W2410578842 hasConceptScore W2410578842C126322002 @default.
• W2410578842 hasConceptScore W2410578842C134018914 @default.
• W2410578842 hasConceptScore W2410578842C178790620 @default.
• W2410578842 hasConceptScore W2410578842C185592680 @default.
• W2410578842 hasConceptScore W2410578842C19038510 @default.
• W2410578842 hasConceptScore W2410578842C25498285 @default.

• next