FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410611566> ?p ?o ?g. }

• W2410611566 endingPage "161" @default.
• W2410611566 startingPage "149" @default.
• W2410611566 abstract "E-proteins are basic helix-loop-helix (bHLH) transcription factors with essential roles in animal development. In mammals, these are encoded by three loci: E2-2 (ITF-2/ME2/SEF2/TCF4), E2A (TCF3), and HEB (ME1/REB/TCF12). The HEB and E2-2 paralogs are expressed as alternative (Alt) isoforms with distinct N-terminal sequences encoded by unique exons under separate regulatory control. Expression of these alternative transcripts is restricted relative to the longer (Can) forms, suggesting distinct regulatory roles, although the functions of the Alt proteins remain poorly understood. Here, we characterize the single sea urchin E-protein ortholog (SpE-protein). The organization of the SpE-protein gene closely resembles that of the extended HEB/E2-2 vertebrate loci, including a transcript that initiates at a homologous alternative transcription start site (SpE-Alt). The existence of an Alt form in the sea urchin indicates that this feature predates the emergence of the vertebrates. We present additional evidence indicating that this transcript was present in the common bilaterian ancestor. In contrast to the widely expressed canonical form (SpE-Can), SpE-Alt expression is tightly restricted. SpE-Alt is expressed in two phases: first in aboral non-skeletogenic mesenchyme (NSM) cells and then in oral NSM cells preceding their differentiation and ingression into the blastocoel. Derivatives of these cells mediate immune response in the larval stage. Inhibition of SpE-Alt activity interferes with these events. Notably, although the two isoforms are initially co-expressed, as these cells differentiate, SpE-Can is excluded from the SpE-Alt+ cell population. This mutually exclusive expression is dependent on SpE-Alt function, which reveals a previously undescribed negative regulatory linkage between the two E-protein forms. Collectively, these findings reorient our understanding of the evolution of this transcription factor family and highlight fundamental properties of E-protein biology." @default.
• W2410611566 created "2016-06-24" @default.
• W2410611566 creator A5004190008 @default.
• W2410611566 creator A5038890159 @default.
• W2410611566 creator A5064724604 @default.
• W2410611566 creator A5065644705 @default.
• W2410611566 creator A5074067452 @default.
• W2410611566 date "2016-08-01" @default.
• W2410611566 modified "2023-09-30" @default.
• W2410611566 title "A conserved alternative form of the purple sea urchin HEB/E2-2/E2A transcription factor mediates a switch in E-protein regulatory state in differentiating immune cells" @default.
• W2410611566 cites W1510054530 @default.
• W2410611566 cites W1537776120 @default.
• W2410611566 cites W1557798994 @default.
• W2410611566 cites W1577835623 @default.
• W2410611566 cites W1580316172 @default.
• W2410611566 cites W1966021458 @default.
• W2410611566 cites W1970056549 @default.
• W2410611566 cites W1973010579 @default.
• W2410611566 cites W1973770084 @default.
• W2410611566 cites W1989297216 @default.
• W2410611566 cites W1992051385 @default.
• W2410611566 cites W1996610645 @default.
• W2410611566 cites W2005665114 @default.
• W2410611566 cites W2007984480 @default.
• W2410611566 cites W2008205503 @default.
• W2410611566 cites W2008664813 @default.
• W2410611566 cites W2013545053 @default.
• W2410611566 cites W2016137413 @default.
• W2410611566 cites W2022032892 @default.
• W2410611566 cites W2022339270 @default.
• W2410611566 cites W2036901235 @default.
• W2410611566 cites W2039898945 @default.
• W2410611566 cites W2041401980 @default.
• W2410611566 cites W2046501667 @default.
• W2410611566 cites W2046979654 @default.
• W2410611566 cites W2050000554 @default.
• W2410611566 cites W2055167848 @default.
• W2410611566 cites W2059529537 @default.
• W2410611566 cites W2060178110 @default.
• W2410611566 cites W2061041720 @default.
• W2410611566 cites W2069077266 @default.
• W2410611566 cites W2071148354 @default.
• W2410611566 cites W2073168126 @default.
• W2410611566 cites W2074040006 @default.
• W2410611566 cites W2082670705 @default.
• W2410611566 cites W2085336503 @default.
• W2410611566 cites W2085625330 @default.
• W2410611566 cites W2086889826 @default.
• W2410611566 cites W2087461579 @default.
• W2410611566 cites W2091578910 @default.
• W2410611566 cites W2094074349 @default.
• W2410611566 cites W2097401587 @default.
• W2410611566 cites W2098791954 @default.
• W2410611566 cites W2102631576 @default.
• W2410611566 cites W2104444887 @default.
• W2410611566 cites W2107997395 @default.
• W2410611566 cites W2108490725 @default.
• W2410611566 cites W2109719547 @default.
• W2410611566 cites W2112067247 @default.
• W2410611566 cites W2114160230 @default.
• W2410611566 cites W2114293379 @default.
• W2410611566 cites W2116242175 @default.
• W2410611566 cites W2117986427 @default.
• W2410611566 cites W2119483052 @default.
• W2410611566 cites W2120494111 @default.
• W2410611566 cites W2123195495 @default.
• W2410611566 cites W2127754056 @default.
• W2410611566 cites W2128948251 @default.
• W2410611566 cites W2129834040 @default.
• W2410611566 cites W2136670217 @default.
• W2410611566 cites W2142553004 @default.
• W2410611566 cites W2144447876 @default.
• W2410611566 cites W2146446591 @default.
• W2410611566 cites W2150901760 @default.
• W2410611566 cites W2152027165 @default.
• W2410611566 cites W2152973976 @default.
• W2410611566 cites W2154403718 @default.
• W2410611566 cites W2166919377 @default.
• W2410611566 cites W2188853866 @default.
• W2410611566 doi "https://doi.org/10.1016/j.ydbio.2016.05.034" @default.
• W2410611566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27265865" @default.
• W2410611566 hasPublicationYear "2016" @default.
• W2410611566 type Work @default.
• W2410611566 sameAs 2410611566 @default.
• W2410611566 citedByCount "21" @default.
• W2410611566 countsByYear W24106115662016 @default.
• W2410611566 countsByYear W24106115662017 @default.
• W2410611566 countsByYear W24106115662018 @default.
• W2410611566 countsByYear W24106115662019 @default.
• W2410611566 countsByYear W24106115662020 @default.
• W2410611566 countsByYear W24106115662021 @default.
• W2410611566 countsByYear W24106115662022 @default.
• W2410611566 countsByYear W24106115662023 @default.
• W2410611566 crossrefType "journal-article" @default.
• W2410611566 hasAuthorship W2410611566A5004190008 @default.
• W2410611566 hasAuthorship W2410611566A5038890159 @default.
• W2410611566 hasAuthorship W2410611566A5064724604 @default.
• W2410611566 hasAuthorship W2410611566A5065644705 @default.

• next