Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410614925> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2410614925 abstract "Introduction Current diagnostic technology for syphilis is over 100 years old and relies on detection of either reagins or treponemal antibodies. The development of new tests formulated on the basis of host cellular response may allow for improved diagnosis and clinical management. We aimed to pilot an evaluation of sera cytokine profiles as a means to better understand the pathogenesis of early infections. Methods Participants included men who have sex with men and transgender women with and without early syphilis recruited at two sexual health clinics in Lima, Peru. Median fluorescence intensity (MFI) of 63 cytokines in serum collected on day of diagnosis was measured using Luminex (eBioscience). We calculated the relative change in MFI between those with active (RPR titer ≥1:32, TPPA+) versus no syphilis infection (TPPA-) and compared groups using a two-sample t-test. Results Among 5 participants with active syphilis infections and 5 without there were 11 cytokines that differed between the groups with a p-value Conclusion Cytokines associated with cellular immune response might be useful in differentiating those needing treatment for active syphilis from those not requiring treatment. All of the cytokines presented here are higher in the active syphilis group versus syphilis uninfected except for Eotaxin. Larger sample size and longitudinal data are required to characterise cytokine profiles associated with treatment response and cure. Identifying cytokine changes may provide a new opportunity for diagnostic testing for syphilis infection. Disclosure of interest statement None." @default.
- W2410614925 created "2016-06-24" @default.
- W2410614925 creator A5016367653 @default.
- W2410614925 creator A5020233165 @default.
- W2410614925 creator A5035416695 @default.
- W2410614925 creator A5038648163 @default.
- W2410614925 creator A5052250407 @default.
- W2410614925 creator A5054161932 @default.
- W2410614925 creator A5068399737 @default.
- W2410614925 creator A5077559189 @default.
- W2410614925 date "2015-09-01" @default.
- W2410614925 modified "2023-10-02" @default.
- W2410614925 title "P07.21 Serum cytokine analysis among patients with and without early syphilis infection" @default.
- W2410614925 doi "https://doi.org/10.1136/sextrans-2015-052270.337" @default.
- W2410614925 hasPublicationYear "2015" @default.
- W2410614925 type Work @default.
- W2410614925 sameAs 2410614925 @default.
- W2410614925 citedByCount "0" @default.
- W2410614925 crossrefType "journal-article" @default.
- W2410614925 hasAuthorship W2410614925A5016367653 @default.
- W2410614925 hasAuthorship W2410614925A5020233165 @default.
- W2410614925 hasAuthorship W2410614925A5035416695 @default.
- W2410614925 hasAuthorship W2410614925A5038648163 @default.
- W2410614925 hasAuthorship W2410614925A5052250407 @default.
- W2410614925 hasAuthorship W2410614925A5054161932 @default.
- W2410614925 hasAuthorship W2410614925A5068399737 @default.
- W2410614925 hasAuthorship W2410614925A5077559189 @default.
- W2410614925 hasBestOaLocation W24106149251 @default.
- W2410614925 hasConcept C126322002 @default.
- W2410614925 hasConcept C203014093 @default.
- W2410614925 hasConcept C2776983459 @default.
- W2410614925 hasConcept C2778690821 @default.
- W2410614925 hasConcept C2780187896 @default.
- W2410614925 hasConcept C3013748606 @default.
- W2410614925 hasConcept C71924100 @default.
- W2410614925 hasConcept C8891405 @default.
- W2410614925 hasConceptScore W2410614925C126322002 @default.
- W2410614925 hasConceptScore W2410614925C203014093 @default.
- W2410614925 hasConceptScore W2410614925C2776983459 @default.
- W2410614925 hasConceptScore W2410614925C2778690821 @default.
- W2410614925 hasConceptScore W2410614925C2780187896 @default.
- W2410614925 hasConceptScore W2410614925C3013748606 @default.
- W2410614925 hasConceptScore W2410614925C71924100 @default.
- W2410614925 hasConceptScore W2410614925C8891405 @default.
- W2410614925 hasLocation W24106149251 @default.
- W2410614925 hasOpenAccess W2410614925 @default.
- W2410614925 hasPrimaryLocation W24106149251 @default.
- W2410614925 hasRelatedWork W2011031787 @default.
- W2410614925 hasRelatedWork W2081293545 @default.
- W2410614925 hasRelatedWork W2112085369 @default.
- W2410614925 hasRelatedWork W2338595770 @default.
- W2410614925 hasRelatedWork W2350097342 @default.
- W2410614925 hasRelatedWork W2380940789 @default.
- W2410614925 hasRelatedWork W2395036598 @default.
- W2410614925 hasRelatedWork W2404226651 @default.
- W2410614925 hasRelatedWork W2745159571 @default.
- W2410614925 hasRelatedWork W2762343217 @default.
- W2410614925 hasRelatedWork W2797414411 @default.
- W2410614925 hasRelatedWork W2883663908 @default.
- W2410614925 hasRelatedWork W2902327740 @default.
- W2410614925 hasRelatedWork W3011418283 @default.
- W2410614925 hasRelatedWork W3022308815 @default.
- W2410614925 hasRelatedWork W3043599667 @default.
- W2410614925 hasRelatedWork W3138473942 @default.
- W2410614925 hasRelatedWork W3144013302 @default.
- W2410614925 hasRelatedWork W3159884550 @default.
- W2410614925 hasRelatedWork W3139894700 @default.
- W2410614925 isParatext "false" @default.
- W2410614925 isRetracted "false" @default.
- W2410614925 magId "2410614925" @default.
- W2410614925 workType "article" @default.