FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410642644> ?p ?o ?g. }

• W2410642644 endingPage "A9" @default.
• W2410642644 startingPage "A9.1" @default.
• W2410642644 abstract "<h3>Introduction</h3> Following the FDA approval trial of the self-expanding Wingspan® Stent System for symptomatic intracranial atherosclerotic disease in which a 4.5% periprocedural complication rate was seen, favorable registry data was reported and subsequently, the prospective randomized SAMMPRIS trial, using the device in an IDE application, not for its original approval, demonstrated poor clinical results with a 14.7% periprocedural complication rate. The WEAVE (Wingspan Stent System Post Market Surveillance Study) Trial is a prospective, consecutive enrollment, single-arm, post market surveillance trial evaluating periprocedural outcomes in patients with the revised FDA indications for use. <h3>Methods</h3> Data for the first 50 patients for which completed data is available are included in this report. The primary analysis endpoints included periprocedural stroke or death within 72 h of the stenting procedure in patients who were treated on label. On label indication included patients with 70% or greater intracranial stenosis due to atherosclerotic disease, with evidence of two prior strokes in the target artery territory, with at least one of the events occurring with preventive comprehensive medical therapy which includes medication to control individual risk factors and at least one antithrombotic medication, and stenting greater than 7 days following the most recent qualifying stroke. Half of the participating sites included anti-platelet therapy resistance testing and correction, if needed, in their treatment of the patient. Patient outcomes were separately assessed by an independent stroke Neurologist at 96 (+/- 24) hours for subjects discharged prior to 64 h post procedure. <h3>Results</h3> In the initial 50 patients enrolled with completed data, 45 patients were treated on label and are included in the  primary analysis, and 5 patients were treated off label. The mean stenosis in the primary analysis group was 83.3% with target artery break down as follows: 41.7% MCA, 18.8% ICA, 16.7% Basilar, 18.8% Vertebral or VB junction. Of the 45 patients in the primary analysis, 2 patients (4.4%) reached a primary endpoint of stroke, or death within 72 h. In the off label group, 3 of the 5 patients reached a primary endpoint within that period. <h3>Conclusions</h3> The early interim analysis of the first 50 patients of the WEAVE Trial has demonstrated a very low periprocedural morbidity and mortality of 4.4% for patients treated on label. This is lower than the high periprocedural event rate in the SAMMPRIS trial, and better than the outcomes in the off label group. This early data provides impetus to continue to collect data in this trial, and lends support to the concept that refined patient selection criteria and establishment of best  practice techniques and management for these patients can substantially decrease the periprocedural risk of intracranial stenting. <h3>Disclosures</h3> M. Alexander: 2; C; Stryker Neurovascular. A. Zauner: 2; C; Stryker Neurovascular. J. Chaloupka: 2; C; Stryker Neurovascular. B. Baxter: 2; C; Stryker Neurovascular. R. Callison: 2; C; Styker Neurovascular. W. Yu: 2; C; Stryker Neurovascular." @default.
• W2410642644 created "2016-06-24" @default.
• W2410642644 creator A5002357227 @default.
• W2410642644 creator A5008352682 @default.
• W2410642644 creator A5043655160 @default.
• W2410642644 creator A5059808760 @default.
• W2410642644 creator A5061653080 @default.
• W2410642644 creator A5075512128 @default.
• W2410642644 date "2015-07-01" @default.
• W2410642644 modified "2023-09-28" @default.
• W2410642644 title "O-016 interim report on the weave™ intracranial stent trial: 50 consecutive patients" @default.
• W2410642644 doi "https://doi.org/10.1136/neurintsurg-2015-011917.16" @default.
• W2410642644 hasPublicationYear "2015" @default.
• W2410642644 type Work @default.
• W2410642644 sameAs 2410642644 @default.
• W2410642644 citedByCount "1" @default.
• W2410642644 countsByYear W24106426442016 @default.
• W2410642644 crossrefType "journal-article" @default.
• W2410642644 hasAuthorship W2410642644A5002357227 @default.
• W2410642644 hasAuthorship W2410642644A5008352682 @default.
• W2410642644 hasAuthorship W2410642644A5043655160 @default.
• W2410642644 hasAuthorship W2410642644A5059808760 @default.
• W2410642644 hasAuthorship W2410642644A5061653080 @default.
• W2410642644 hasAuthorship W2410642644A5075512128 @default.
• W2410642644 hasConcept C126322002 @default.
• W2410642644 hasConcept C127413603 @default.
• W2410642644 hasConcept C141071460 @default.
• W2410642644 hasConcept C168563851 @default.
• W2410642644 hasConcept C203092338 @default.
• W2410642644 hasConcept C2778583881 @default.
• W2410642644 hasConcept C2780007028 @default.
• W2410642644 hasConcept C2780645631 @default.
• W2410642644 hasConcept C535046627 @default.
• W2410642644 hasConcept C61943457 @default.
• W2410642644 hasConcept C71924100 @default.
• W2410642644 hasConcept C78519656 @default.
• W2410642644 hasConceptScore W2410642644C126322002 @default.
• W2410642644 hasConceptScore W2410642644C127413603 @default.
• W2410642644 hasConceptScore W2410642644C141071460 @default.
• W2410642644 hasConceptScore W2410642644C168563851 @default.
• W2410642644 hasConceptScore W2410642644C203092338 @default.
• W2410642644 hasConceptScore W2410642644C2778583881 @default.
• W2410642644 hasConceptScore W2410642644C2780007028 @default.
• W2410642644 hasConceptScore W2410642644C2780645631 @default.
• W2410642644 hasConceptScore W2410642644C535046627 @default.
• W2410642644 hasConceptScore W2410642644C61943457 @default.
• W2410642644 hasConceptScore W2410642644C71924100 @default.
• W2410642644 hasConceptScore W2410642644C78519656 @default.
• W2410642644 hasIssue "Suppl 1" @default.
• W2410642644 hasLocation W24106426441 @default.
• W2410642644 hasOpenAccess W2410642644 @default.
• W2410642644 hasPrimaryLocation W24106426441 @default.
• W2410642644 hasRelatedWork W1977125423 @default.
• W2410642644 hasRelatedWork W2011249355 @default.
• W2410642644 hasRelatedWork W2074420293 @default.
• W2410642644 hasRelatedWork W2114983792 @default.
• W2410642644 hasRelatedWork W2950976910 @default.
• W2410642644 hasRelatedWork W2956014051 @default.
• W2410642644 hasRelatedWork W3082225243 @default.
• W2410642644 hasRelatedWork W388644598 @default.
• W2410642644 hasRelatedWork W4224272955 @default.
• W2410642644 hasRelatedWork W4291019541 @default.
• W2410642644 hasVolume "7" @default.
• W2410642644 isParatext "false" @default.
• W2410642644 isRetracted "false" @default.
• W2410642644 magId "2410642644" @default.
• W2410642644 workType "article" @default.