FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410645950> ?p ?o ?g. }

• W2410645950 endingPage "16" @default.
• W2410645950 startingPage "1" @default.
• W2410645950 abstract "Bacterial translocation is defined as the passage of viable bacteria from the gastrointestinal (GI) tract through the mucosal epithelium to other sites, such as the mesenteric lymph nodes, spleen, liver and blood. This paper reviews results from animal models utilized to obtain information concerning the defense mechanisms opera-ting in the healthy host to confine bacteria to the GI tract. Gnotobiotic and antibiotic-decontaminated mice colonized with particular bacteria demonstrated that the indi-genous GI flora maintains an ecologic equilibrium to prevent intestinal bacterial overgrowth and translocation from the GI tract. Studies with athymic (nu/nu) mice, thymus-graf ted (nu/nu) mice, neonatally thymectomized mice, and mice injected with immunosuppressive agents demonstrated that the host immune system is another defense mechanism inhibiting bacterial translocation from the GI tract. Ricinoleic acid given orally to mice disrupted the intestinal epithelial barrier allowing indigenous bacteria to translocate from the GI tract. Thus, bacterial translocation from the GI tract of healthy adult mice is inhibited by : (a) an intact intestinal epithelial barrier, (b) the host immune defense system, and (c) an indigenous GI flora maintaining ecological equilibrium to prevent bacterial overgrowth.Deficiencies in host defense mechanisms act synergistically to promote bacterial translocation from the GI tract as demonstrated by animal models with multiple alterations in host defenses. Bacterial translocation occurred to a greater degree in mice with streptozotocin-induced diabetes, mice receiving nonlethal thermal injury, and mice receiving the combination of an immunosuppressive agent plus an oral antibiotic than in mice with only a primary alteration in host defenses. The study of bacterial translocation in these complex models suggests that opportunistic infections from the GI tract occur in discrete stages. In the healthy adult animal, bacterial translocation from the GI tract either does not occur or occurs at a very low level and the host immune defenses eliminate the translocating bacteria. Bacterial translocation does take place if one of the host defense mechanisms is compromised, such as a deficiency in the immune response, bacterial overgrowth in the intestines, or an increase in the permeability of the intestinal barrier. In this first stage, the bacteria usually translocate in low numbers to the mesenteric lymph node, and sometimes spleen or liver, but do not multiply and spread systemically. Bacteria translocate to other organs includ-ing the blood and peritoneal cavity, however, in animals exhibiting multiple alterations in their defense mechanisms, such as immunodef iciency in combination with bacterial overgrowth. In the third stage, the alterations in host defenses are severe enough to allow the translocating bacteria to produce septicemia and death. Thus, bacterial translocation from the GI tract is an important early event in the pathogenesis of certain opportunistic infections." @default.
• W2410645950 created "2016-06-24" @default.
• W2410645950 creator A5049868490 @default.
• W2410645950 date "1985-01-01" @default.
• W2410645950 modified "2023-10-11" @default.
• W2410645950 title "Bacterial Translocation from the Intestines" @default.
• W2410645950 cites W108698287 @default.
• W2410645950 cites W1496795923 @default.
• W2410645950 cites W1512547662 @default.
• W2410645950 cites W1522861838 @default.
• W2410645950 cites W1540775234 @default.
• W2410645950 cites W1579409600 @default.
• W2410645950 cites W1588326804 @default.
• W2410645950 cites W1692894082 @default.
• W2410645950 cites W1905885715 @default.
• W2410645950 cites W1917049859 @default.
• W2410645950 cites W1952384394 @default.
• W2410645950 cites W1959757802 @default.
• W2410645950 cites W1964992187 @default.
• W2410645950 cites W1979297836 @default.
• W2410645950 cites W1983871071 @default.
• W2410645950 cites W1993823185 @default.
• W2410645950 cites W2000679823 @default.
• W2410645950 cites W2001211617 @default.
• W2410645950 cites W2001682664 @default.
• W2410645950 cites W2007031838 @default.
• W2410645950 cites W2013330486 @default.
• W2410645950 cites W2014202337 @default.
• W2410645950 cites W2019302863 @default.
• W2410645950 cites W2021223384 @default.
• W2410645950 cites W2024863918 @default.
• W2410645950 cites W2026938048 @default.
• W2410645950 cites W2031958547 @default.
• W2410645950 cites W2032080191 @default.
• W2410645950 cites W2036089151 @default.
• W2410645950 cites W2049052083 @default.
• W2410645950 cites W2050490859 @default.
• W2410645950 cites W2051063972 @default.
• W2410645950 cites W2052518216 @default.
• W2410645950 cites W2052884083 @default.
• W2410645950 cites W2063703864 @default.
• W2410645950 cites W2065965955 @default.
• W2410645950 cites W2082175810 @default.
• W2410645950 cites W2086174860 @default.
• W2410645950 cites W2094603450 @default.
• W2410645950 cites W2095314093 @default.
• W2410645950 cites W2103373188 @default.
• W2410645950 cites W2111359516 @default.
• W2410645950 cites W2113792102 @default.
• W2410645950 cites W2116819525 @default.
• W2410645950 cites W2150501935 @default.
• W2410645950 cites W2154415865 @default.
• W2410645950 cites W2162523534 @default.
• W2410645950 cites W2249657875 @default.
• W2410645950 cites W2293924372 @default.
• W2410645950 cites W2312279215 @default.
• W2410645950 cites W2326214050 @default.
• W2410645950 cites W2333911155 @default.
• W2410645950 cites W2399810453 @default.
• W2410645950 cites W2419665419 @default.
• W2410645950 cites W2440416991 @default.
• W2410645950 cites W286043179 @default.
• W2410645950 cites W2897458762 @default.
• W2410645950 cites W635065840 @default.
• W2410645950 cites W1578471575 @default.
• W2410645950 doi "https://doi.org/10.1538/expanim1978.34.1_1" @default.
• W2410645950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3987819" @default.
• W2410645950 hasPublicationYear "1985" @default.
• W2410645950 type Work @default.
• W2410645950 sameAs 2410645950 @default.
• W2410645950 citedByCount "39" @default.
• W2410645950 countsByYear W24106459502014 @default.
• W2410645950 countsByYear W24106459502016 @default.
• W2410645950 countsByYear W24106459502018 @default.
• W2410645950 countsByYear W24106459502019 @default.
• W2410645950 countsByYear W24106459502022 @default.
• W2410645950 countsByYear W24106459502023 @default.
• W2410645950 crossrefType "journal-article" @default.
• W2410645950 hasAuthorship W2410645950A5049868490 @default.
• W2410645950 hasBestOaLocation W24106459501 @default.
• W2410645950 hasConcept C104317684 @default.
• W2410645950 hasConcept C126831891 @default.
• W2410645950 hasConcept C138626823 @default.
• W2410645950 hasConcept C18903297 @default.
• W2410645950 hasConcept C203014093 @default.
• W2410645950 hasConcept C2779237934 @default.
• W2410645950 hasConcept C2780512811 @default.
• W2410645950 hasConcept C2780931953 @default.
• W2410645950 hasConcept C2781077229 @default.
• W2410645950 hasConcept C523546767 @default.
• W2410645950 hasConcept C529295009 @default.
• W2410645950 hasConcept C54355233 @default.
• W2410645950 hasConcept C55493867 @default.
• W2410645950 hasConcept C86803240 @default.
• W2410645950 hasConcept C8891405 @default.
• W2410645950 hasConcept C89423630 @default.
• W2410645950 hasConceptScore W2410645950C104317684 @default.
• W2410645950 hasConceptScore W2410645950C126831891 @default.

• next