Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410698032> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2410698032 endingPage "L884" @default.
- W2410698032 startingPage "L879" @default.
- W2410698032 abstract "Studies were carried out to evaluate the mechanism by which neurotransmission through airway parasympathetic ganglia may be modulated during immediate hypersensitivity reactions. Guinea pigs were passively sensitized by injection of guinea pig serum containing high-titer anti-ovalbumin antibodies. Intracellular recordings were obtained from intrinsic parasympathetic ganglion neurons from the right mainstem bronchus in vitro. Ovalbumin (10 micrograms/ml) elicited a membrane potential depolarization and changes in membrane resistance in bronchial ganglion neurons from passively sensitized guinea pigs. Histamine mimicked the depolarizing effect of ovalbumin in a concentration-dependent manner (0.1-10 microM) and caused a transient increase and decrease in membrane resistance. Pyrilamine, a histamine H1-receptor antagonist, inhibited the histamine-induced membrane depolarization and decrease in resistance. By contrast, blocking histamine H2 and H3 receptors did not inhibit histamine-induced depolarization. Pyrilamine also reduced the antigen-induced depolarization of ganglion neurons, demonstrating a role for histamine H1 receptors in this response. The data provide evidence that the antigen-induced depolarization of airway ganglion neurons is secondary to an antigen-antibody interaction on intrinsic mast cells and the consequential effect of histamine on H1 receptors. These studies demonstrate that histamine released during an immediate hypersensitivity reaction has direct effects on airway parasympathetic nerves." @default.
- W2410698032 created "2016-06-24" @default.
- W2410698032 creator A5002877424 @default.
- W2410698032 creator A5004911440 @default.
- W2410698032 date "1995-06-01" @default.
- W2410698032 modified "2023-10-16" @default.
- W2410698032 title "Antigen depolarizes guinea pig bronchial parasympathetic ganglion neurons by activation of histamine H1 receptors" @default.
- W2410698032 doi "https://doi.org/10.1152/ajplung.1995.268.6.l879" @default.
- W2410698032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7611429" @default.
- W2410698032 hasPublicationYear "1995" @default.
- W2410698032 type Work @default.
- W2410698032 sameAs 2410698032 @default.
- W2410698032 citedByCount "14" @default.
- W2410698032 countsByYear W24106980322012 @default.
- W2410698032 countsByYear W24106980322014 @default.
- W2410698032 countsByYear W24106980322019 @default.
- W2410698032 crossrefType "journal-article" @default.
- W2410698032 hasAuthorship W2410698032A5002877424 @default.
- W2410698032 hasAuthorship W2410698032A5004911440 @default.
- W2410698032 hasConcept C10335311 @default.
- W2410698032 hasConcept C1122143 @default.
- W2410698032 hasConcept C126322002 @default.
- W2410698032 hasConcept C134018914 @default.
- W2410698032 hasConcept C147483822 @default.
- W2410698032 hasConcept C159545944 @default.
- W2410698032 hasConcept C170493617 @default.
- W2410698032 hasConcept C185592680 @default.
- W2410698032 hasConcept C203014093 @default.
- W2410698032 hasConcept C2776885963 @default.
- W2410698032 hasConcept C2776946954 @default.
- W2410698032 hasConcept C2910759140 @default.
- W2410698032 hasConcept C4141045 @default.
- W2410698032 hasConcept C63180777 @default.
- W2410698032 hasConcept C71924100 @default.
- W2410698032 hasConcept C86803240 @default.
- W2410698032 hasConceptScore W2410698032C10335311 @default.
- W2410698032 hasConceptScore W2410698032C1122143 @default.
- W2410698032 hasConceptScore W2410698032C126322002 @default.
- W2410698032 hasConceptScore W2410698032C134018914 @default.
- W2410698032 hasConceptScore W2410698032C147483822 @default.
- W2410698032 hasConceptScore W2410698032C159545944 @default.
- W2410698032 hasConceptScore W2410698032C170493617 @default.
- W2410698032 hasConceptScore W2410698032C185592680 @default.
- W2410698032 hasConceptScore W2410698032C203014093 @default.
- W2410698032 hasConceptScore W2410698032C2776885963 @default.
- W2410698032 hasConceptScore W2410698032C2776946954 @default.
- W2410698032 hasConceptScore W2410698032C2910759140 @default.
- W2410698032 hasConceptScore W2410698032C4141045 @default.
- W2410698032 hasConceptScore W2410698032C63180777 @default.
- W2410698032 hasConceptScore W2410698032C71924100 @default.
- W2410698032 hasConceptScore W2410698032C86803240 @default.
- W2410698032 hasIssue "6" @default.
- W2410698032 hasLocation W24106980321 @default.
- W2410698032 hasLocation W24106980322 @default.
- W2410698032 hasOpenAccess W2410698032 @default.
- W2410698032 hasPrimaryLocation W24106980321 @default.
- W2410698032 hasRelatedWork W2005373223 @default.
- W2410698032 hasRelatedWork W2072172784 @default.
- W2410698032 hasRelatedWork W2076906435 @default.
- W2410698032 hasRelatedWork W2079980862 @default.
- W2410698032 hasRelatedWork W2178080980 @default.
- W2410698032 hasRelatedWork W2407812270 @default.
- W2410698032 hasRelatedWork W2410182397 @default.
- W2410698032 hasRelatedWork W2410698032 @default.
- W2410698032 hasRelatedWork W2522836974 @default.
- W2410698032 hasRelatedWork W2943326462 @default.
- W2410698032 hasVolume "268" @default.
- W2410698032 isParatext "false" @default.
- W2410698032 isRetracted "false" @default.
- W2410698032 magId "2410698032" @default.
- W2410698032 workType "article" @default.