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• W2410746166 abstract "Abstract Objectives (-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. This study was aimed to assess the anti-ulcerogenic potential of (-)-myrtenol against ethanol-induced gastric lesions and to elucidate the underlying mechanism(s). Methods Gastroprotective activity of (-)-myrtenol was evaluated using the mouse model of ethanol-induced gastric damage. To elucidate the gastroprotective mechanism(s), the roles of GABA, prostaglandins, nitric oxide and KATP channels were assessed. Besides, the oxidative stress-related parameters and the mucus content in gastric tissues were analysed. Key findings (-)-Myrtenol at oral doses of 25, 50 and 100 mg/kg significantly decreased the severity of ethanol-induced gastric lesions affording gastroprotection that was accompanied by a decrease in the activity of myeloperoxidase and malondialdehyde, an increase in GPx, SOD, and catalase activity in gastric tissues, and with well-maintained normal levels of nitrite/nitrate, gastric mucus and NP-SHs. Pretreatment with GABA-A receptor antagonist flumazenil, the COX inhibitor indomethacin, and NO synthesis inhibitor L-NAME but not with KATP channel blocker glibenclamide significantly blocked the (-)-myrtenol gastroprotection. Conclusion These results provide first-time evidence for the gastroprotective effect of (-)-myrtenol that could be related to GABAA-receptor activation and antioxidant activity." @default.
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• W2410746166 date "2016-06-12" @default.
• W2410746166 modified "2023-10-01" @default.
• W2410746166 title "Gastroprotective effect of (-)-myrtenol against ethanol-induced acute gastric lesions: possible mechanisms" @default.
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• W2410746166 doi "https://doi.org/10.1111/jphp.12583" @default.
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