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• W2410802890 abstract "No AccessJournal of Urology1 Nov 1987Effects of Some Calcium Channel Blockers on Isolated Human Penile Erectile Tissues Magnus Fovaeus, Karl-Erik Andersson, and Hans Hedlund Magnus FovaeusMagnus Fovaeus More articles by this author , Karl-Erik AnderssonKarl-Erik Andersson More articles by this author , and Hans HedlundHans Hedlund More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43582-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The effects of the calcium channel blockers (CCBs) verapamil, nifedipine and diltiazem on contractile activation of isolated human penile erectile tissues were investigated. Specimens of the corpus spongiosum (CS) and corpora cavernosa (CC) were obtained from men with a history of normal penile erection undergoing cystourethrectomy because of bladder malignancy. Preparations were mounted in organ baths and isometric tension was recorded. Deprivation of extracellular calcium abolished electrically induced contractions in both CS and CC preparations within 15min.; norepinephrine (NE)-induced contractions were reduced by 90% (CS) and 83% (CC) after 30min. All the CCBs reduced electrically induced contractions concentration-dependently, nifedipine being the most potent agent. Contractions induced by exogenous NE were depressed by about 50%, whereas high K+ (124mM) induced responses were abolished. It is concluded that contraction in penile erectile tissues is mediated mainly by neuronally released NE stimulating postjunctional alpha-adrenoceptors. The contraction is highly dependent on extracellular calcium and can partly be inhibited by CCBs. It cannot be excluded that some CCBs injected intracavernosally may be useful for diagnosis and even treatment of erectile dysfunction. However, calcium channel blockade may not be as effective as a therapeutic principle as blockade of alpha-adrenoceptors. © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byCHOI Y, CHUNG W and CHOI H (2018) THE ACTION MECHANISM OF RELAXATION EFFECT OF ATROPINE ON THE ISOLATED RABBIT CORPUS CAVERNOSUMJournal of Urology, VOL. 161, NO. 6, (1976-1979), Online publication date: 1-Jun-1999.De Tejada I, Kim N, Daley J, Royai R, Hypolite J, Broderick G, Garcia-Diaz F and Levin R (2018) Acidosis Impairs Rabbit Trabecular Smooth Muscle ContractilityJournal of Urology, VOL. 157, NO. 2, (722-726), Online publication date: 1-Feb-1997.Kerfoot W, Young Park H, Schwartz L, Hagen P and Carson C (2018) Characterization of Calcium Channel Blocker Induced Smooth Muscle Relaxation Using a Model of Isolated Corpus CavernosumJournal of Urology, VOL. 150, NO. 1, (249-252), Online publication date: 1-Jul-1993.Holmquist F, Persson K, Garcia-Pascual A and Andersson K (2018) Phospholipase C Activation by Endothelin-1 and Noradrenaline in Isolated Penile Erectile Tissue from RabbitJournal of Urology, VOL. 147, NO. 6, (1632-1635), Online publication date: 1-Jun-1992.Holmquist F, Andersson K, Fovaeus M and Hedlund H (2018) K+-Channel Openers for Relaxation of Isolated Penile Erectile Tissue from RabbitJournal of Urology, VOL. 144, NO. 1, (146-151), Online publication date: 1-Jul-1990. Volume 138Issue 5November 1987Page: 1267-1272 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Magnus Fovaeus More articles by this author Karl-Erik Andersson More articles by this author Hans Hedlund More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2410802890 title "Effects of Some Calcium Channel Blockers on Isolated Human Penile Erectile Tissues" @default.
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